Ohuchi, Kentaro Kambayashi, Yumi Hidaka, Takanori Fujimura, Taku
Published in
Frontiers in Oncology
Plasminogen activating inhibitor-1 (PAI-1) plays crucial roles in the development of various cancers, including melanomas. Indeed, various pro-tumorigenic functions of PAI-1 in cancer progression and metastasis have been widely reported. Among them, PAI-1 is also reported as a key regulator of PD-L1 expression on melanoma cells through endocytosis,...
Zhang, Hongxia Wu, Guangsheng Feng, Junjian Lu, Xiaohong Liu, Ping
Published in
Journal of Orthopaedic Surgery and Research
BackgroundThis study aimed to investigate the effects of STOML2 and the relationship between STOML2 and PAI-1 in the development of multiple myeloma (MM).MethodsCell proliferation was tested using CCK-8 assay and cell colony formation assay. Glucose consumption, lactate production and ATP level were measured using commercial kits. The mRNA and prot...
Ghosh, Asish K Soberanes, Saul Lux, Elizabeth Shang, Meng Aillon, Raul Piseaux Eren, Mesut Budinger, G R Scott Miyata, Toshio Vaughan, Douglas E
Published in
Environmental pollution (Barking, Essex : 1987)
Numerous studies have established that acute or chronic exposure to environmental pollutants like particulate matter (PM) leads to the development of accelerated aging related pathologies including pulmonary and cardiovascular diseases, and thus air pollution is one of the major global threats to human health. Air pollutant particulate matter 2.5 (...
Spillane, Cathy D. Cooke, Niamh M. Ward, Mark P. Kenny, Dermot Blackshields, Gordon Kelly, Tanya Bates, Mark Huang, Yanmei Martin, Cara Skehan, Sinead
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Published in
Translational Oncology
Tumour metastasis accounts for over 90% of cancer related deaths. The platelet is a key blood component, which facilitates efficient metastasis. This study aimed to understand the molecular mechanisms involved in tumour-platelet cell interactions. The interaction between cancer cells and platelets was examined in 15 epithelial cell lines, represent...
Wang, Jiaxi Peng, Yuanyuan Guo, Hejia Li, Cuiping
Published in
Technology in Cancer Research & Treatment
Background: The plasminogen activator inhibitor-1 (PAI-1) was found in many types of tumor cells, which involved in tumorigenesis. Some studies investigated the associations between PAI-1 polymorphisms and various cancers, but the results were inconsistent. So this study did a meta-analysis to assess the strength of relationship between PAI-1 and c...
Paniagua-Sancho, María Quiros, Yaremi Casanova, Alfredo G. Blanco-Gozalo, Víctor Agüeros-Blanco, Consuelo Benito-Hernández, Adalberto Ramos-Barron, María A. Gómez-Alamillo, Carlos Arias, Manuel Sancho-Martínez, Sandra M.
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Published in
American Journal of Nephrology
Introduction: Acute kidney injury (AKI) is a threatening, multiaetiological syndrome encompassing a variety of forms and damage patterns. AKI lacks sufficiently specific diagnostic tools to evaluate the distinct combination of pathophysiological events underlying each case, which limits personalized and optimized handling. Therefore, a pathophysiol...
Lin, Yu-Sen Kuo, Ting-Ting Lo, Chia-Chien Cheng, Wei-Chung Chang, Wei-Chao Tseng, Guan-Chin Bai, Shih-Ting Huang, Yu-Kai Hsieh, Chih-Ying Hsu, Han-Shui
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Published in
International journal of biological sciences
Hypoxia and angiogenesis play key roles in the pathogenesis of esophageal squamous cell carcinoma (ESCC), but regulators linking these two pathways to drive tumor progression remain elusive. Here we provide evidence of ADAM9's novel function in ESCC progression. Increasing expression of ADAM9 was correlated with poor clinical outcomes in ESCC patie...
Fuchs, Anja Samovski, Dmitri Smith, Gordon I Cifarelli, Vincenza Farabi, Sarah S Yoshino, Jun Pietka, Terri Chang, Shin-Wen Ghosh, Sarbani Myckatyn, Terence M
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Published in
Gastroenterology
Insulin resistance is a key factor in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). We evaluated the importance of subcutaneous abdominal adipose tissue (SAAT) inflammation and both plasma and SAAT-derived exosomes in regulating insulin sensitivity in people with obesity and NAFLD. Adipose tissue inflammation (macrophage and T-cell ...
Connolly, Nina P Galisteo, Rebeca Xu, Su Bar, Eli E Peng, Sen Tran, Nhan L Ames, Heather M Kim, Anthony J Woodworth, Graeme F Winkles, Jeffrey A
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Published in
Glia
High-grade gliomas (HGGs) are aggressive, treatment-resistant, and often fatal human brain cancers. The TNF-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) signaling axis is involved in tissue repair after injury and constitutive signaling has been implicated in the pathogenesis of numerous solid cancers. The Fn1...
Liberale, Luca Akhmedov, Alexander Vlachogiannis, Nikolaos I Bonetti, Nicole R Nageswaran, Vanasa Miranda, Melroy X Puspitasari, Yustina M Schwarz, Lena Costantino, Sarah Paneni, Francesco
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Published in
Cardiovascular research
Arterial thrombosis as a result of plaque rupture or erosion is a key event in acute cardiovascular events. Sirtuin 5 (SIRT5) belongs to the lifespan-regulating sirtuin superfamily and has been implicated in acute ischaemic stroke and cardiac hypertrophy. This project aims at investigating the role of SIRT5 in arterial thrombus formation. Sirt5 tra...
