DDX5 potentiates HIV-1 transcription as a co-factor of Tat
10.1186/s12977-020-00514-4 / Retrovirology / 17 / 1 / 6
CDK9: Therapeutic Perspective in HCC Therapy.
Published in Current cancer drug targets
CDK9 is an important cell-cycle control enzyme essential in transcription, elongation, and mRNA maturation. Overexpression of CDK9 has been reported in several diseases, including acute lymphoblastic leukemia, chronic lymphocytic leukemia, and malignant melanoma. Recent research revealed that CDK9-inhibitors have a major impact on the induction of ...
Bromodomain and Extraterminal Inhibition by JQ1 Produces Divergent Transcriptional Regulation of Suppressors of Cytokine...
Published in Endocrinology
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway has cell-specific functions. Suppressors of cytokine signaling (SOCS) proteins are negative-feedback regulators of JAK-STAT signaling. STAT5 plays a significant role in adipocyte development and function, and bromodomain and extraterminal (BET) proteins m...
The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors.
...Published in Development (Cambridge, England)
Multipotent progenitor populations are necessary for generating diverse tissue types during embryogenesis. We show the RNA polymerase-associated factor 1 complex (Paf1C) is required to maintain multipotent progenitors of the neural crest (NC) lineage in zebrafish. Mutations affecting each Paf1C component result in near-identical NC phenotypes; alyr...
Targeting cyclin-dependent kinase 9 sensitizes medulloblastoma cells to chemotherapy.
Published in Biochemical and biophysical research communications
Medulloblastoma (MB) is a highly aggressive, malignant brain tumor in children with poor prognosis. Cyclin-dependent kinase 9 (CDK9), a serine-threonine kinase, is widely implicated in the control of basal gene expression by phosphorylating Serine 2 (Ser2) of the heptad repeat in the RNA Polymerase II (RNA Pol II) C-terminal domain (CTD). Although ...
Latency-Reversing Agents Induce Differential Responses in Distinct Memory CD4 T Cell Subsets in Individuals on Antiretro...
Published in Cell reports
Latent proviruses persist in central (TCM), transitional (TTM), and effector (TEM) memory cells. We measured the levels of cellular factors involved in HIV gene expression in these subsets. The highest levels of acetylated H4, active nuclear factor κB (NF-κB), and active positive transcription elongation factor b (P-TEFb) were measured in TEM, TCM,...
Contrôle de l'expression génique par la RNP 7SK
Le facteur positif de l'élongation P-TEFb stimule l'élongation de la transcription par l'ARN Polymérase II (ARN Pol II) en phosphorylant les facteurs négatifs de l'élongation et le domaine carboxy-terminal (CTD) de l'ARN Pol II. L'activité nucléaire de P-TEFb est contrôlée par la particule ribonucléoprotéique (RNP) 7SK, composée du petit ARN nucléa...
DDX5 potentiates HIV-1 transcription as a co-factor of Tat
Funder: Cambridge Biomedical Research Centre (GB) / Funder: Clinical Academic Reserve / Abstract: Background: HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recently shown to be associated with...
DDX5 potentiates HIV-1 transcription as a co-factor of Tat
Funder: Cambridge Biomedical Research Centre (GB) / Funder: Clinical Academic Reserve / Abstract: Background: HIV-1 does not encode a helicase and hijacks those of the cell for efficient replication. We and others previously showed that the DEAD box helicase, DDX5, is an essential HIV dependency factor. DDX5 was recently shown to be associated with...
Tyr1 phosphorylation promotes phosphorylation of Ser2 on the C-terminal domain of eukaryotic RNA polymerase II by P-TEFb...
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Published in eLife
The Positive Transcription Elongation Factor b (P-TEFb) phosphorylates Ser2 residues of the C-terminal domain (CTD) of the largest subunit (RPB1) of RNA polymerase II and is essential for the transition from transcription initiation to elongation in vivo. Surprisingly, P-TEFb exhibits Ser5 phosphorylation activity in vitro. The mechanism garnering ...
