Published in AIDS Research and Therapy
BackgroundThe management of visceral leishmaniasis (VL) in HIV-infected patients is often complex with patients experiencing higher mortality rates, more toxic side effects and a higher possibility of treatment failure and relapse than HIV-negative individuals with VL.Case presentationWe report on successful salvage therapy in two HIV-infected pati...
Published in Principles and Practice of Transplant Infectious Diseases
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) has become a widely used modality of therapy for a variety of malignant and nonmalignant diseases. Despite advances in pharmacotherapy and transplantation techniques, infection remains one of the most severe and frequently encountered complications of allo-HSCT. This chapter will addres...
Published in AIDS (London, England)
In a prospective study of genital HSV shedding in HIV and HSV-2 infected persons, the rate of HSV-2 shedding was highest within 90 days of initiation of ART, then decreased by 2% for every month on ART. Shedding rate was higher in untreated persons with higher plasma HIV RNA.
Published in Fungal Diversity
Numerous agents of infections in humans and other mammals are found among fungi that are able to survive extreme environmental conditions and to quickly adapt to novel habitats. Nevertheless, the relationship between opportunistic potential and polyextremotolerance was not yet studied systematically in fungi. Here, the link between polyextremotoler...
Published in Neurologic clinics
Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the ...
Published in BMC Infectious Diseases
BackgroundClostridium ramosum is a generally non-pathogenic enteric anaerobe, and Fournier’s gangrene is a rare necrotizing soft tissue infection with male predisposition affecting the perineum and the genital area. We report, to our knowledge, the first case of Fournier’s gangrene caused by C. ramosum in a female patient with multiple underlying c...
Published in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
Cytomegalovirus (CMV) infection is associated with relapse and exacerbation of ulcerative colitis (UC), especially in immunosuppressed patients. The aim of this study was to identify risk factors for CMV colitis and to develop a predictive risk score to estimate the probability of CMV colitis in UC patients supporting clinical decision making. A co...
Published in Current Clinical Microbiology Reports
Purpose of ReviewDespite the increasing number of clinical reports on immune reconstitution inflammatory syndrome (IRIS), mechanistic understanding of IRIS is still largely limited. The main focus of this review is to summarize animal studies, which were performed to better understand the cellular and molecular mechanisms underlying the pathology o...
Published in Journal of community medicine (Reno, Nev.)
Infection is the second most common cause of esophagitis, second only to gastroesophageal reflux, and represents a clinically important disorder. Immunosuppressed patients are at highest risk for infectious esophagitis, with CANDIDA, herpes simplex virus, and cytomegalovirus being the most common causative microorganisms. Here we provide a brief cl...
Published in Infectious disease clinics of North America
Biologics target various pathways to modify immunologic activity. Biologic use to treat pediatric patients continues to expand; but limited data exist regarding infectious complications of these agents, especially for newer agents. Infectious events reported in the literature for pediatric patients indicate that a variety of bacterial, mycobacteria...
