Early histochemical changes in irradiated salivary glands and lymph‐nodes of the rat
The inhibition of ribosomal RNA synthesis and maturation in Novikoff hepatoma cells by 5-fluorouridine.
The inhibition of ribosomal RNA (rRNA) maturation by 5-fluorouridine (FUrd) in Novikoff hepatoma cells appears to depend upon the incorporation of the analog into the 45 S rRNA precursor. Precursor synthesized in the presence of FUrd is not processed into mature rRNA, but precursor synthesized in the absence of the analog is processed normally afte...
Studies on FeSV induced sarcomata in sheep with particular reference to the regional lymphatic system
Inocula of cultured sheep cells that had been transformed with FeSV were injected into the legs of sheep so that the changes in the cellular and humoral composition of the efferent lymph from the regional node could be studied throughout the immune responses. The times at which immunoblasts and specific antibodies appeared in the lymph were similar...
The role of orchiectomy in the management of advanced male breast cancer
Nine men with advanced carcinoma of the breast were evaluated after orchiectomy at the National Institutes of Health over 19 years. Of patients followed for greater than one year, five had complete remissions, one had a partial remission, and two patients did not respond to orchiectomy. The average disease-free interval was 20 months; the average s...
Male breast cancer: a review
Inhibition of human melanoma colony formation by retinoids.
We studied the effects of retinoids on the in vitro survival of melanoma colony-forming cells in biopsies obtained from ten patients with metastatic melanoma. The results indicate that specific retinoids reduce the ability of fresh human melanoma cells to form colonies in soft agar. The retinoids studied had differential effects on the survival of ...
Satellite DNA sequences and reproductive isolation in theDrosophila willistoni group
Satellite DNAs of the Drosophila willistoni group have been analyzed by Hae III endonuclease digestion. Differences were observed between the 2 species D. willistoni and D. paulistorum and also between semispecies of D. paulistorum and, to a lesser extent, between subspecies of D. willistoni. Differences did not appear to be consistently greater be...
New drugs in ovarian cancer and malignant melanoma: in vitro phase II screening with the human tumor stem cell assay.
The successful development of a soft agar clonogenic assay for human tumor stem cells provides an in vitro technique with a high degree of accuracy for predicting in vivo clinical response to standard anticancer drugs. We used this system to conduct an "in vitro phase II trial" in human ovarian cancer and melanoma. This approach can potentially ide...
Correlation of collagen synthesis and procollagen messenger RNA levels with transformation in rat embryo fibroblasts.
A line of normal rat embryo fibroblasts was transformed with N-methyl-N'-nitro-N-nitrosoguanidine (a chemical carcinogen), SV40 and polyoma virus (two DNA viruses), and Rous sarcoma virus (an RNA tumor virus). In this study, we report a comparison of the levels of collagen synthesis and procollagen messenger RNA (mRNA) in 13 lines selected after tr...
Mice, men, mustards and methylated xanthines: the potential role of caffeine and related drugs in the sensitization of h...
The relationships between DNA damage from UV radiation, alkylating drugs and the methylated xanthines (MX) have been studied in normal and malignant rodent and human cells. A comparison of the level of DNA excision repair (repair replication and unscheduled DNA synthesis) confirms that some forms of alkylating-agent damage (probably mono-filar DNA ...
