Brain tissue obtained at autopsy continues to provide unique opportunities in current dementia research. Not only is tissue analysis still essential for diagnosis, but investigation of neurochemical pathology, at a level of resolution beyond current in vivo imaging, continues to provide new insights into the involvement of neurotransmitter signalli...
Schizophrenia is a diffuse brain disease that affects many facets of cognitive function. One of the most replicated findings in the neurobiology of schizophrenia is that the event-related potentials to auditory oddball stimuli are abnormal, suggesting abnormalities in attention and memory processes. Recently, we have used event-related fMRI to eluc...
10.1212/wnl.57.5.805 / NEUROLOGY / 57 / 5 / 805-811 / United States
Transfection and subsequent expression of DNA in living neuronal tissue is problematic and no technique has emerged that is completely non-damaging, efficient and reproducible. The Bio-Rad hand-held GeneGun has overcome some of these problems by exploiting a biolistic method in which small gold particles carrying plasmid DNA are propelled into neur...
10.1097/00001756-200207020-00021 / NEUROREPORT / 13 / 9 / 1175-1178 / United States
HIPPOCAMPUS / 13 / 2 / 260-272
Converging evidence from studies of event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI) suggest that criminal psycho- pathy is associated with abnormalities in limbic and paralimbic brain regions during a variety of cognitive and affective tasks. These results have led to the hypothesis that the paralimbic system is dys...
We employed functional magnetic resonance imaging (fMRI) on two separate occasions (6-8 weeks apart) to investigate neurophysiological changes in acutely psychotic first episode schizophrenic patients and demographically matched controls during performance of the N-Back working memory task. The task consisted of 2-back (find letter identical to one p...
The mechanism of bulk membrane uptake at the synapse remains poorly defined, although exocytosis of synaptic vesicles is followed by compensatory membrane retrieval into both small vesicles and large cisternas or vacuoles. We investigated bulk retrieval in the presynaptic terminal of retinal bipolar cells. Fluorescence imaging of the membrane dye F...
10.1016/S0006-8993(03)02554-X / BRAIN RESEARCH / 974 / 1-Feb / 82-87 / NETHERLANDS
