Ultrastructural changes in the hypothalamic supraoptic nucleus of the streptozotocin-induced diabetic rat
Journal of Anatomy / 184 / 3 / 615-623 / JOANA
Ultrastructural changes in the hypothalamic supraoptic nucleus of the streptozotocin-induced diabetic rat
Journal of Anatomy / 184 / 3 / 615-623 / JOANA
Cerebrospinal fluid neuropeptides in Alzheimer's disease and vascular dementia
Published in Biological Psychiatry
Cerebrospinal fluid (CSF) levels of several neuropeptides have been suggested as candidate markers in neurodegenerative disorders. We have examined the levels of corticotropin-releasing hormone (CRH), beta-endorphine (BEND), delta sleep-inducing peptide (DSIP), somatostatin (SRIF), and neuropeptide Y (NPY) in CSF samples obtained under highly stand...
Borna disease virus and the brain.
Published in Brain research bulletin
Viruses with the ability to establish persistent infection in the central nervous system (CNS) can induce progressive neurologic disorders associated with diverse pathological manifestations. Clinical, epidemiological, and virological evidence supports the hypothesis that viruses contribute to human mental diseases whose etiology remains elusive. T...
Differential expression of apolipoprotein D and apolipoprotein E in the kainic acid-lesioned rat hippocampus
10.1016/S0306-4522(96)00608-2 / Neuroscience / 79 / 2 / 359-367 / NRSCD
Neurodegeneration induced by MoMuLV-ts1 and increased expression of Fas and TNF-αin the central nervous system
Published in Brain Research
Abstract Infection of neonatal mice with ts1, the neuropathogenic mutant of the Moloney murine leukemia virus, results in motor neuronal death in the brainstem and the spinal cord, with gliosis and demyelination, but no inflammatory cell infiltration into the CNS. To evaluate the possible mechanism(s) of ts1-induced neuropathogenesis, we measured C...
A New Locus for Autosomal Recessive Hereditary Spastic Paraplegia Maps to Chromosome 16q24.3
...Published in The American Journal of Human Genetics
Summary Hereditary spastic paraplegia is a genetically and phenotypically heterogeneous disorder. Both pure and complicated forms have been described, with autosomal dominant, autosomal recessive, and X-linked inheritance. Various loci (SPG1–SPG6) associated with this disorder have been mapped. Here, we report linkage analysis of a large consanguin...
Genetic Association of Apolipoprotein E with Age-Related Macular Degeneration
Published in The American Journal of Human Genetics
Summary Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness and is characterized by degeneration of the neuroepithelium in the macular area of the eye. Apolipoprotein E (apoE), the major apolipoprotein of the CNS and an important regulator of cholesterol and lipid transport, appears to be associated...
Effects of the 3-hydroxyanthranilic acid analogue NCR-631 on anoxia-, IL-1β- and LPS-induced hippocampal pyramidal cell ...
Published in Amino Acids
The kynurenine pathway intermediate 3-hydroxyanthranilic acid (3-HANA) is converted by 3-HANA 3,4-dioxygenase (3-HAO) to the putative neuropathogen quinolinic acid (QUIN). In the present study, the neuroprotective effects of the 3-HANA analogue and 3-HAO inhibitor NCR-631 was investigated using organotypic cultures of rat hippocampus. An anoxic les...
Spinal nerve lesion induces upregulation of neuronal nitric oxide synthase in the spinal cord
Published in Amino Acids
The possibility nitric oxide (NO) is involved the neurodegenrative mechanisms in the spinal cord following a chronic peripheral nerve lesion was examined using NOS immunohistochemistry. Spinal nerve lesion at L-5 and L-6 level was produced according to the Chung model, a model of neuropathic pain and rats were allowed to survive for 8 weeks. In one...
