Guha, Sanjib Fischer, Sarah Johnson, Gail V. W. Nehrke, Keith
Published in
Molecular Neurodegeneration
BackgroundA defining pathological hallmark of the progressive neurodegenerative disorder Alzheimer’s disease (AD) is the accumulation of misfolded tau with abnormal post-translational modifications (PTMs). These include phosphorylation at Threonine 231 (T231) and acetylation at Lysine 274 (K274) and at Lysine 281 (K281). Although tau is recognized ...
Quinn, Peter M. J. Moreira, Paula I. Ambrósio, António Francisco Alves, C. Henrique
Published in
Acta Neuropathologica Communications
Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson’s disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous mitochondria, thus fine-tuning mitochondrial network an...
Rodríguez-Pascau, Laura Britti, Elena Calap-Quintana, Pablo Dong, Yi Na Vergara, Cristina Delaspre, Fabien Medina-Carbonero, Marta Tamarit, Jordi Pallardó, Federico V Gonzalez-Cabo, Pilar
...
Published in
Neurobiology of disease
Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts, cardiomyopathy, and increased incidence in diabetes. The underlying pathophysiological mechanism of FRDA, driven by a significantly decreased expression of frataxin (FXN), involves increased...
Han, Sha Fei, Fei Sun, Shaoyang Zhang, Dongyang Dong, Qiang Wang, Xu Wang, Liang
Published in
Biochemical and biophysical research communications
Serpini1, which encodes neuroserpin, has been implicated in the development and normal function of the nervous system. Mutations in serpini1 cause familial encephalopathy, a rare neurodegenerative disorder characterized with neuroserpin inclusion bodies. However, function of neuroserpin in the nervous system is not fully understood. In this study, ...
Silva, Diana F. Candeias, Emanuel Esteves, A. Raquel Magalhães, João D. Ferreira, I. Luísa Nunes-Costa, Daniela Rego, A. Cristina Empadinhas, Nuno Cardoso, Sandra M.
Published in
Journal of Neuroinflammation
BackgroundAfter decades of research recognizing it as a complex multifactorial disorder, sporadic Alzheimer’s disease (sAD) still has no known etiology. Adding to the myriad of different pathways involved, bacterial neurotoxins are assuming greater importance in the etiology and/or progression of sAD. β-N-Methylamino-l-alanine (BMAA), a neurotoxin ...
Uddin, Md Sahab Al Mamun, Abdullah Kabir, Md Tanvir Ahmad, Jamil Jeandet, Philippe Sarwar, Md Shahid Ashraf, Ghulam Md Aleya, Lotfi
Published in
European journal of pharmacology
Neurodegenerative diseases (NDs) are characterized by disorders with progressive deterioration of the structure and/or function of neurons. Genetic mutations can lead to many NDs. Nevertheless, neurodegeneration can also take place due to several biological processes. The pathogenesis of several NDs including Alzheimer's (AD), Parkinson's (PD), and...
Tapa, Srinivas Wang, Lianguo Francis Stuart, Samantha D. Wang, Zhen Jiang, Yanyan Habecker, Beth A. Ripplinger, Crystal M.
Published in
Scientific Reports
Myocardial infarction (MI) can result in sympathetic nerve loss in the infarct region. However, the contribution of hypo-innervation to electrophysiological remodeling, independent from MI-induced ischemia and fibrosis, has not been comprehensively investigated. We present a novel mouse model of regional cardiac sympathetic hypo-innervation utilizi...
Soltani, Reza Boroujeni, Mahdi Eskandarian Aghajanpour, Fakhroddin Khatmi, Aysan Ezi, Samira Mirbehbahani, Seyed Hamidreza Abdollahifar, Mohammad-Amin Akhlaghpasand, Mohamadhosein Aliaghaei, Abbas Heidari, Mohammad-Hasan
...
Published in
Journal of chemical neuroanatomy
Tramadol is a synthetic analogue of codeine, mostly prescribed for the alleviation of mild to moderate pains. It bears several side effects including emotional instability and anxiety. In this study, we focused on the alteration in expression of autophagic and apoptotic genes in PC-12 cells for our in vitro and structural and functional changes of ...
Pietroboni, Anna M Carandini, Tiziana Dell'Arti, Laura Bovis, Francesca Colombi, Annalisa De Riz, Milena A Casazza, Elena Scola, Elisa Fenoglio, Chiara Arighi, Andrea
...
Published in
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Neurodegenerative processes are present since the early stages of multiple sclerosis (MS), constituting the primary substrate of disability. As part of the CNS, retinal damage could be considered a reliable prognostic biomarker of neurodegeneration in MS. To characterize longitudinal changes in the retinal layers' thickness and to investigate corre...
Huang, Chunhui Yan, Sen Zhang, Zaijun
Published in
Translational Neurodegeneration
Mitochondria are the energy center of cell operations and are involved in physiological functions and maintenance of metabolic balance and homeostasis in the body. Alterations of mitochondrial function are associated with a variety of degenerative and acute diseases. As mitochondria age in cells, they gradually become inefficient and potentially to...
