Dolatshahi, Mahsa Sabahi, Mohammadmahdi Aarabi, Mohammad Hadi
Published in
Molecular neurobiology
Along with emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, a myriad of neurologic symptoms, associated with structural brain changes, were reported. In this paper, we provide evidence to critically discuss the claim that the survived patients could possibly be at increased risk for neurodegenerative...
Takaichi, Yuta Chambers, James K. Takahashi, Kei Soeda, Yoshiyuki Koike, Riki Katsumata, Etsuko Kita, Chiaki Matsuda, Fuko Haritani, Makoto Takashima, Akihiko
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Published in
Acta Neuropathologica Communications
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) as senile plaques and cerebral amyloid angiopathy, and hyperphosphorylated tau (hp-tau) as neurofibrillary tangles in the brain. The AD-related pathology has been reported in several non-human animals, and most animals develop only the Aβ or tau pathology. We herein des...
Zaiter, Jamila Hibot, Achraf Hafid, Abderrafia Khouili, Mostafa Neves, Claudia M B Simões, Mário M Q Neves, M Graça P M S Faustino, M Amparo F Dagci, Taner Saso, Luciano
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Published in
European journal of medicinal chemistry
The loss of neurons is strongly correlated with aging and aging-associated disorders. In this study, cell viability assays and mitochondrial function were performed to evaluate the effect of new spiro-pyrazole derivatives, prepared from aldehydes and 3-amino-1-phenyl-2-pyrazolin-5-one, on neuroprotection in an in vitro model of dopaminergic cell de...
Picone, Pasquale Porcelli, Gaetana Bavisotto, Celeste Caruso Nuzzo, Domenico Galizzi, Giacoma Biagio, Pier Luigi San Bulone, Donatella Di Carlo, Marta
Published in
Journal of Nanobiotechnology
BackgroundMitochondrial dysfunction is a critical factor in the onset and progression of neurodegenerative diseases. Recently, mitochondrial transplantation has been advised as an innovative and attractive strategy to transfer and replace damaged mitochondria. Here we propose, for the first time, to use rat brain extracted synaptosomes, a subcellul...
Bevins, Elizabeth A. Peters, Jonathan Léger, Gabriel C.
Published in
Current Treatment Options in Neurology
Purpose of ReviewThis article discusses the diagnostic evaluation and management of reversible dementia syndromes. It highlights clinical syndromes and explores the recent literature implicating certain reversible factors in Alzheimer’s disease pathogenesis.Recent FindingsThe prevalence of fully reversible dementia is low, but there is growing awar...
Wang, Peng Ye, Yihong
Published in
Nature Communications
The mechanisms underlying the transmission of Tau in astrocytes are unclear. Here, the authors show that the entry of filamentous recombinant human Tau into astrocytes via the integrin αV/ β1 complex stimulates integrin signaling, resulting in activation of NFκB and astrocyte conversion towards a neurotoxic state.
Mehta, Arpan R. Gregory, Jenna M. Dando, Owen Carter, Roderick N. Burr, Karen Nanda, Jyoti Story, David McDade, Karina Smith, Colin Morton, Nicholas M.
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Published in
Acta Neuropathologica
Axonal dysfunction is a common phenotype in neurodegenerative disorders, including in amyotrophic lateral sclerosis (ALS), where the key pathological cell-type, the motor neuron (MN), has an axon extending up to a metre long. The maintenance of axonal function is a highly energy-demanding process, raising the question of whether MN cellular energet...
Vicente-Gutiérrez, Carlos Jiménez-Blasco, Daniel Quintana-Cabrera, Rubén
Published in
Neurochemical research
Metabolism and redox signalling share critical nodes in the nervous system. In the last years, a series of major findings have challenged the current vision on how neural reactive oxygen species (ROS) are produced and handled in the nervous system. Once regarded as deleterious by-products, ROS are now shown to be essential for a metabolic and redox...
Zattoni, Marco Garrovo, Chiara Xerxa, Elena Spigolon, Giada Fisone, Gilberto Kristensson, Krister Legname, Giuseppe
Published in
Cellular and molecular neurobiology
Transmissible neurodegenerative prion diseases are characterized by the conversion of the cellular prion protein (PrPC) to misfolded isoforms denoted as prions or PrPSc. Although the conversion can occur in the test tube containing recombinant prion protein or cell lysates, efficient prion formation depends on the integrity of intact cell functions...
Kilbride, Seán M Telford, Jayne E Davey, Gavin P
Published in
Neurochemical research
Reductions in the activities of mitochondrial electron transport chain (ETC) enzymes have been implicated in the pathogenesis of numerous chronic neurodegenerative disorders. Maintenance of the mitochondrial membrane potential (Δψm) is a primary function of these enzyme complexes, and is essential for ATP production and neuronal survival. We examin...
