Kepp, Kasper Planeta
Human neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis involve protein aggregation and share many other similarities. It is widely assumed that the protein aggregates exhibit a specific molecular mode of toxic action that propagates by molecular contact (seeding). This article presents a...
Nuzzo, Domenico Baldassano, Sara Amato, Antonella Picone, Pasquale Galizzi, Giacoma Caldara, Gaetano Felice Di Carlo, Marta Mulè, Flavia
Published in
Neurobiology of disease
Growing evidence suggests a link between obesity and neurodegeneration. The purpose of the present study was to explore the neuroprotective potential of glucagon-like peptide-2 (GLP-2) in the brain of high fat diet (HFD)-fed mice. Markers of inflammation and oxidative stress were analysed in the brains of obese mice chronically treated with [Gly2]-...
Linsley, Jeremy W Tripathi, Atmiyata Epstein, Irina Schmunk, Galina Mount, Elliot Campioni, Matthew Oza, Viral Barch, Mariya Javaherian, Ashkan Nowakowski, Tomasz J
...
Current approaches for dynamic profiling of single cells rely on dissociated cultures, which lack important biological features existing in tissues. Organotypic slice cultures preserve aspects of structural and synaptic organisation within the brain and are amenable to microscopy, but established techniques are not well adapted for high throughput ...
Zarb, Yvette Franzoso, Francesca Daniela Keller, Annika
Published in
Advances in experimental medicine and biology
Pericytes are perivascular cells along capillaries that are critical for the development of a functional vascular bed in the central nervous system and other organs. Pericyte functions in the adult brain are less well understood. Pericytes have been suggested to mediate functional hyperemia at the capillary level, regulate the blood-brain barrier a...
Mozaffari, Shiva Ramezany Yasuj, Sanaz Motaghinejad, Majid Motevalian, Manijeh Kheiri, Reyhaneh
Published in
Iranian Journal of Pharmaceutical Research : IJPR
Methamphetamine (METH) abuse causes neurodegeneration. Medicinal herb such as crocin has neuroprotective properties. The current study evaluates the role of CREB-BDNF signaling pathway in mediating the neuroprotective effects of crocin against METH-induced neurodegeneration in rats. Sixty adult male rats were divided randomly into group 1 and group...
Jahanbakhsh, Shahriyar
Neurodegenerative diseases such as Parkinson’s and Alzheimer’s affect millions of people and are uniformly untreatable. A significant unmet need exists for faster and higher throughput approaches to modeling neurodegenerative diseases and identifying candidate small molecule therapies. Herein, I present a new chemical biology approach to identifyin...
Ghosh, Arunibha Sadhukhan, Tamal Giri, Subhajit Biswas, Arindam Das, Shyamal Kumar Ray, Kunal Ray, Jharna
BACKGROUND: Parkinson's disease (PD) is the debilitating movement disorder, distinguished by dopaminergic and norepinephrinergic neurodegeneration. Apart from candidate gene mutations, several modifier loci have been reported to be associated with the disease manifestation. The Dopamine β-Hydroxylase (DBH) maintains cellular dopamine content and re...
Niemelä, Valter
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. Reliable biomarkers could empower such trials and gu...
Kepp, Kasper Planeta
Human neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis involve protein aggregation and share many other similarities. It is widely assumed that the protein aggregates exhibit a specific molecular mode of toxic action that propagates by molecular contact (seeding). This article presents a...
Huang, Miaozhen Verbeek, Dineke S
Published in
Neuroscience letters
The genetically heterozygous spinocerebellar ataxias are all characterized by cerebellar atrophy and pervasive Purkinje Cell degeneration. Up to date, more than 35 functionally diverse spinocerebellar ataxia genes have been identified. The main question that remains yet unsolved is why do some many genetic insults lead to Purkinje Cell degeneration...