Tefera, Tesfaye Wolde Steyn, Frederik J. Ngo, Shyuan T. Borges, Karin
Published in
Cell & Bioscience
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder primarily characterized by selective degeneration of both the upper motor neurons in the brain and lower motor neurons in the brain stem and the spinal cord. The exact mechanism for the selective death of neurons is unknown. A growing body of evidence demonstrates...
Tan, Meng-Shan Yang, Yu-Xiang Xu, Wei Wang, Hui-Fu Tan, Lin Zuo, Chuan-Tao Dong, Qiang Tan, Lan Suckling, John Yu, Jin-Tai
...
Published in
Alzheimer's Research & Therapy
BackgroundGenome-wide association studies have identified more than 30 Alzheimer’s disease (AD) risk genes, although the detailed mechanism through which all these genes are associated with AD pathogenesis remains unknown. We comprehensively evaluate the roles of the variants in top 30 non-APOE AD risk genes, based on whether these variants were as...
Dolatshahi, Mahsa Sabahi, Mohammadmahdi Aarabi, Mohammad Hadi
Published in
Molecular neurobiology
Along with emergence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019, a myriad of neurologic symptoms, associated with structural brain changes, were reported. In this paper, we provide evidence to critically discuss the claim that the survived patients could possibly be at increased risk for neurodegenerative...
Takaichi, Yuta Chambers, James K. Takahashi, Kei Soeda, Yoshiyuki Koike, Riki Katsumata, Etsuko Kita, Chiaki Matsuda, Fuko Haritani, Makoto Takashima, Akihiko
...
Published in
Acta Neuropathologica Communications
Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-β (Aβ) as senile plaques and cerebral amyloid angiopathy, and hyperphosphorylated tau (hp-tau) as neurofibrillary tangles in the brain. The AD-related pathology has been reported in several non-human animals, and most animals develop only the Aβ or tau pathology. We herein des...
Picone, Pasquale Porcelli, Gaetana Bavisotto, Celeste Caruso Nuzzo, Domenico Galizzi, Giacoma Biagio, Pier Luigi San Bulone, Donatella Di Carlo, Marta
Published in
Journal of Nanobiotechnology
BackgroundMitochondrial dysfunction is a critical factor in the onset and progression of neurodegenerative diseases. Recently, mitochondrial transplantation has been advised as an innovative and attractive strategy to transfer and replace damaged mitochondria. Here we propose, for the first time, to use rat brain extracted synaptosomes, a subcellul...
Bevins, Elizabeth A. Peters, Jonathan Léger, Gabriel C.
Published in
Current Treatment Options in Neurology
Purpose of ReviewThis article discusses the diagnostic evaluation and management of reversible dementia syndromes. It highlights clinical syndromes and explores the recent literature implicating certain reversible factors in Alzheimer’s disease pathogenesis.Recent FindingsThe prevalence of fully reversible dementia is low, but there is growing awar...
Gou, De-Hai Huang, Ting-Ting Li, Wen Gao, Xin-Di Haikal, Caroline Wang, Xin-He Song, Dong-Yan Liang, Xin Zhu, Lin Tang, Yong
...
Published in
Redox biology
The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson's disease. Copper promotes α-synuclein aggregation and toxicity in vitro. The level of copper and copper transporter 1, which is the only known high-affinity copper importer in the brain, decreases in the substantia nigra of Parkinson's disease patients. However, ...
Thadathil, Nidheesh Delotterie, David F Xiao, Jianfeng Hori, Roderick McDonald, Michael P Khan, Mohammad Moshahid
Published in
Molecular neurobiology
Alzheimer's disease (AD) is a progressive neurodegenerative disease that accounts for a majority of dementia cases. AD is characterized by progressive neuronal death associated with neuropathological lesions consisting of neurofibrillary tangles and senile plaques. While the pathogenesis of AD has been widely investigated, significant gaps in our k...
Jahn, Tabea Clark, Christopher Kerksiek, Anja Lewczuk, Piotr Lütjohann, Dieter Popp, Julius
Published in
The Journal of steroid biochemistry and molecular biology
Altered cholesterol metabolism is associated with increased risk of neurodegeneration and in particular with the development of Alzheimer's disease (AD). Here, we investigate whether non-cholesterol sterols and oxysterols in the central nervous system are associated with (i) the presence of cerebral AD pathology, (ii) distinct aspects of AD patholo...
Rojas, Asheebo McCarren, Hilary S Wang, Jennifer Wang, Wenyi Abreu-Melon, JuanMartin Wang, Sarah McDonough, John H Dingledine, Raymond
Published in
Neurotoxicology
The increasing number of cases involving the use of nerve agents as deadly weapons has spurred investigation into the molecular mechanisms underlying nerve agent-induced pathology. The highly toxic nature of nerve agents restrict their use in academic research laboratories. Less toxic organophosphorus (OP) based agents including diisopropylfluoroph...