Mutua, Victoria Gershwin, Laurel J
Published in
Clinical reviews in allergy & immunology
Activated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of...
Meurer, Marita Öhlmann, Sophie Bonilla, Marta C. Valentin-Weigand, Peter Beineke, Andreas Hennig-Pauka, Isabel Schwerk, Christian Schroten, Horst Baums, Christoph G. von Köckritz-Blickwede, Maren
...
Published in
International Journal of Molecular Sciences
Streptococcus suis is a zoonotic agent causing meningitis in pigs and humans. Neutrophils, as the first line of defense against S. suis infections, release neutrophil extracellular traps (NETs) to entrap pathogens. In this study, we investigated the role of the secreted nuclease A of S. suis (SsnA) as a NET-evasion factor in vivo and in vitro. Pigl...
Finnerty, Dylan T. Buggy, Donal J.
Published in
BJA: British Journal of Anaesthesia
Barbu, Emilia A. Dominical, Venina M. Mendelsohn, Laurel Thein, Swee Lay
Published in
Frontiers in Immunology
Neutrophil extracellular traps (NETs) formation has been implicated in an increasing number of infectious and non-infectious pathologies. NETosis is a tightly regulated process; the end-stage and read-out is the formation of DNA strands extruded from the nuclei, and traditionally assessed by fluorescence microscopy. Since NETosis has emerged as a p...
Cheah, Irwin K. Halliwell, Barry
Published in
Antioxidants
Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive inflammation that can lead to respiratory or multiorgan failure. Numerous studies have established ...
Skarzynski, Dariusz J Szóstek-Mioduchowska, Anna Z Rebordão, Maria Rosa Jalali, Beenu Moza Piotrowska-Tomala, Katarzyna K Leciejewska, Natalia Łazarczyk, Miriam Ferreira-Dias, Graça M
Published in
Theriogenology
The innate and adaptive immune mechanisms are key components of regulation of reproductive physiological function and uterine disorders in equine uterus. The predominant immunological response in equine endometrium, characterized by an innate immune response, occurs under estrogens influence, in the follicular phase. Although, the increase in immun...
Zeng, Jie Xu, Han Fan, Pei-Zhi Xie, Jing He, Jie Yu, Jie Gu, Xianwen Zhang, Chao-Jie
Published in
Journal of cellular and molecular medicine
Kaempferol (kaem) is a dietary flavonoid found in a variety of fruits and vegetables. The inhibitory effects of kaem on primary tumour growth have been extensively investigated; however, its effects on tumour metastasis are largely unknown. In the present study, we found that kaem significantly suppresses both primary tumour growth and lung metasta...
Bilyy, Rostyslav Bila, Galyna Vishchur, Oleg Vovk, Volodymyr Herrmann, Martin
Published in
Nanomaterials
Many nano/microparticles (n/µP), to which our body is exposed, have no physiological way of removal. Our immune system sense these “small particulate objects”, and tries to decrease their harmfulness. Since oxidation, phagocytosis and other methods of degradation do not work with small, chemically resistant, and hydrophobic nanoparticles (nP). This...
fridahl, mathias hansson, anders haikola, simon
The incongruence between the United Nations objective to hold global warming well below 2 ° / C and the rate of global emission reductions has intensified interest in negative emissions. Previous research has explored several pros and cons of individual negative emissions technologies. Systematised approaches to comparing and prioritising among ...
Tomar, Bhawna Anders, Hans-Joachim Desai, Jyaysi Mulay, Shrikant R
Published in
Cells
The COVID-19 pandemic is progressing worldwide with an alarming death toll. There is an urgent need for novel therapeutic strategies to combat potentially fatal complications. Distinctive clinical features of severe COVID-19 include acute respiratory distress syndrome, neutrophilia, and cytokine storm, along with severe inflammatory response syndro...
