Lasky, Joseph A Fuloria, Jyotsna Morrison, Marion E Lanier, Randall Naderer, Odin Brundage, Tom Melemed, Allen
Published in
Advances in therapy
The COVID-19 global pandemic caused by the novel coronavirus, SARS-CoV-2, and the consequent morbidity and mortality attributable to progressive hypoxemia and subsequent respiratory failure threaten to overrun hospital critical care units globally. New agents that address the hyperinflammatory "cytokine storm" and hypercoagulable pathology seen in ...
Vijayvergia, Namrata Dasari, Arvind
Published in
Current Treatment Options in Oncology
Ongoing advances in our understanding of neuroendocrine tumor (NET) biology, genetics, and immunology, will continue to expand the availability of targeted therapies, thus improving the outcomes of patients. Well-differentiated neuroendocrine tumors (NETs) are grouped into pancreatic and non-pancreatic NETs (includes GI and thoracic NETs) for treat...
Essig, Fabian Kollikowski, Alexander M. Pham, Mirko Solymosi, László Stoll, Guido Haeusler, Karl Georg Kraft, Peter Schuhmann, Michael K.
Published in
International Journal of Molecular Sciences
Ischemic stroke caused by thromboembolic occlusion of large cerebral arteries, such as the internal carotid (ICA) and/or the middle cerebral artery (MCA), is treated by mechanical thrombectomy (MT). MT allows salvage of the vessel-occluding thrombemboli, which most frequently originate from the left atrium or the left ventricle of the heart or from...
Lozano, Maria L Garabet, Lamya Fernandez-Perez, Maria Piedad De Los Reyes-García, Ascension M Diaz-Lozano, Pedro Garcia-Barbera, Nuria Aguila, Sonia Vicente, Vicente Ghanima, Waleed Martinez, Constantino
...
Published in
Platelets
No biological predictors for the increased risk of thrombosis in patients with immune thrombocytopenia (ITP) have been identified. The aim of the study was to investigate platelet and neutrophil activation as well neutrophil extracellular trap (NET) formation in 63 ITP patients and 30 healthy volunteers. Platelet and neutrophil activation was asses...
Fartelj, David
Neutrophils represent the majority of all immune cells and are arguably the most important cells of the innate immune system. Their response may be non-specific, but they are one of the first recognition sites against invading microorganisms. They can ingest a variety of pathogens by phagocytosis, destroying them in intracellular vesicles containin...
Wójcik, Piotr Garley, Marzena Wroński, Adam Jabłońska, Ewa Skrzydlewska, Elżbieta
Published in
International Journal of Molecular Sciences
Psoriasis is associated with increased production of reactive oxygen species which leads to oxidative stress. As antioxidants can provide protection, the aim of this study was to evaluate the effects of cannabidiol (CBD) on neutrophil extracellular trap (NET) formation in psoriatic and healthy neutrophils. Important markers of NETosis were measured...
Takahashi, Toshiya Yamasaki, Kenshi
Published in
International Journal of Molecular Sciences
Psoriasis is a systemic inflammatory disease caused by crosstalk between various cells such as T cells, neutrophils, dendritic cells, and keratinocytes. Antimicrobial peptides (AMPs) such as β-defensin, S100, and cathelicidin are secreted from these cells and activate the innate immune system through various mechanisms to induce inflammation, thus ...
Santocki, Michal Kolaczkowska, Elzbieta
Published in
Cells
Although neutrophil extracellular traps (NETs) were discovered only 16 years ago, they have already taken us from heaven to hell as we learned that apart from beneficial trapping of pathogens, they cause, or contribute to, numerous disorders. The latter is connected to their persistent presence in the blood or tissue, and we hardly know how they ar...
Greaney, Allison J Portley, Makayla K O'Mard, Danielle Crown, Devorah Maier, Nolan K Mendenhall, Megan A Mayer-Barber, Katrin D Leppla, Stephen H Moayeri, Mahtab
Published in
Journal of leukocyte biology
Anthrax lethal toxin (LT) is a protease that activates the NLRP1b inflammasome sensor in certain rodent strains. Unlike better-studied sensors, relatively little is known about the priming requirements for NLRP1b. In this study, we investigate the rapid and striking priming-independent LT-induced release of IL-1β in mice within hours of toxin chall...
Nagaoka, Isao Tamura, Hiroshi Reich, Johannes
Published in
International Journal of Molecular Sciences
Among the mechanisms put-up by the host to defend against invading microorganisms, antimicrobial peptides represent the first line. In different species of mammals, the cathelicidin family of antimicrobial peptides AMPs has been identified, and in humans, LL-37 is the only type of cathelicidin identified. LL-37 has many different biological activit...
