Bersin, Theresa V Cordova, Kasey L Saenger, E Kate Journey, Meredith L Beckman, Brian R Lema, Sean C
Published in
Molecular and cellular endocrinology
Insulin-like growth factor-1 (Igf1) regulates skeletal muscle growth in fishes by increasing protein synthesis and promoting muscle hypertrophy. When fish experience periods of insufficient food intake, they undergo slower muscle growth or even muscle wasting, and those changes emerge in part from nutritional modulation of Igf1 signaling. Here, we ...
Zoico, Elena Saatchi, Tanaz Nori, Nicole Mazzali, Gloria Rizzatti, Vanni Pizzi, Eleonora Fantin, Francesco Giani, Anna Urbani, Silvia Zamboni, Mauro
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Published in
Experimental gerontology
Recently, there has been a growing body of evidence showing a negative effect of the white adipose tissue (WAT) dysfunction on the skeletal muscle function and quality. However, little is known about the effects of senescent adipocytes on muscle cells. Therefore, to explore potential mechanisms involved in age-related loss of muscle mass and functi...
Nagai, Hidenari Amanuma, Makoto Mukozu, Takanori Kobayashi, Kojiro Nagumo, Hideki Mohri, Kunihide Watanabe, Go Yoshimine, Naoyuki Ogino, Yu Daido, Yasuko
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Published in
Oncology
Introduction: Previously, we reported that the tyrosine kinase inhibitor (TKI) sorafenib decreases serum levels of carnitine and reduces skeletal muscle volume. Moreover, others reported that TKIs might lead to cardiomyopathy or heart failure. Therefore, this study aimed to evaluate the effects of lenvatinib (LEN) on skeletal muscle volume and card...
Lee, Se-Jin Bhasin, Shalender Klickstein, Lloyd Krishnan, Venkatesh Rooks, Daniel
Published in
The journals of gerontology. Series A, Biological sciences and medical sciences
Over the past 25 years, considerable progress has been made in terms of elucidating the regulatory and signaling mechanisms underlying the control of skeletal muscle mass by myostatin and other secreted proteins belonging to the transforming growth factor-β superfamily. Preclinical studies demonstrating the potential benefits of targeting the activ...
Martin, Agnès Gallot, Yann S Freyssenet, Damien
Published in
Journal of cachexia, sarcopenia and muscle
Cancer cachexia is a systemic hypoanabolic and catabolic syndrome that diminishes the quality of life of cancer patients, decreases the efficiency of therapeutic strategies and ultimately contributes to decrease their lifespan. The depletion of skeletal muscle compartment, which represents the primary site of protein loss during cancer cachexia, is...
Jakubina, Pauline Meloux, Alexandre Duloquin, Gauthier Aho, Serge Vergely, Catherine Béjot, Yannick
Published in
Journal of the neurological sciences
Identifying biological markers of ischemic stroke (IS) is an important research approach to develop innovative therapeutic strategies. This study aimed to assess the association between plasma Growth Differentiation Factor-8 (GDF-8)/Myostatin levels and outcome of IS patients. Consecutive patients with acute IS treated with either intravenous throm...
Mitra, Akash Qaisar, Rizwan Bose, Bipasha Sudheer, Shenoy P
Published in
Osteoporosis and Sarcopenia
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Lian, John Walker, Ryan G D'Amico, Andrea Vujic, Ana Mills, Melanie J Messemer, Kathleen A Mendello, Kourtney R Goldstein, Jill M Leacock, Krystynne A Epp, Soraya
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Growth differentiation factor 11 (GDF11) and GDF8 (MSTN) are closely related TGF-β family proteins that interact with nearly identical signaling receptors and antagonists. However, GDF11 appears to activate SMAD2/3 more potently than GDF8 in vitro and in vivo. The ligands possess divergent structural properties, whereby substituting unique GDF11 am...
Ziyaiyan, Amirhosein Kordi, Mohammadreza Hofmeister, Martin Chamari, Karim Moalla, Wassim Gaeini, Abbas Ali
Published in
BMC Sports Science, Medicine and Rehabilitation
Background Skeletal muscle contractions due to exercise lead to the secretion of many proteins and proteoglycan peptides called myokines. Myostatin (MSTN) and Myogenin (MyoG) are two of the most important skeletal muscle growth regulatory factors related to myoblast differentiation and muscle hypertrophy. The present study aims at investigating the...
SOUZA, C. B. de MENEZES, G. R. de O. GUIMARÃES, S. E. F.
Resumo - Bovinos da raça Senepol são acometidos pela síndrome da dupla musculatura (DM), condição hereditária responsável por diversas alterações fenotípicas. A mutação responsável pela DM está localizada no gene codificador da miostatina (GDF – 8), com a deleção de 11 pares de base denominada como nt821. Diante disto, o objetivo deste trabalho foi...
