A human bladder cencer cell line resistant to adriamycin (ADM), T-24/ADM was establishied in vitro by exposing T-24 parent cells to a progressively higher concentration of the drug over an 18 month period. The T-24/ADM was 34.9 times more resistant to ADM than the T-24 parent. The T-24/ADM exhibited cross resistance to ADM derivatives, vinca alkalo...
Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters is associated with prostate cancer drug resistance and progression J Hao1,2, H Chen1,2, MC Madigan3, PJ Cozzi1,4, J B...
Through exposure to melphalan or taxol, four novel multidrug resistant variants of the human nasal carcinoma cell line, RPMI-2650 and human lung carcinoma cell line, DLKP, were established In vitro toxicity tests revealed that the RPMI-2650 taxol-resistant variant exhibited significant resistance to taxol, vincristine, adriamycin and vinblastine. T...
Through exposure to melphalan or taxol, four novel multidrug resistant variants of the human nasal carcinoma cell line, RPMI-2650 and human lung carcinoma cell line, DLKP, were established In vitro toxicity tests revealed that the RPMI-2650 taxol-resistant variant exhibited significant resistance to taxol, vincristine, adriamycin and vinblastine. T...
Cholera is a severe diarrhoeal illness caused by certain strains of Vibrio cholerae, which can lead rapidly to dehydration and death. Communities dependent on water contaminated with human faeces and those with poor sanitation are very vulnerable to cholera epidemics. Although theVibrio cholerae Ol El Tor strain presently circulating in southern Af...
