AIMS: To discuss the various aspects associated with the emergence of carbapenem resistance in isolates of Acinetobacter baumannii and the spread of epidemic clones. SOURCE OF DATA: We consulted the databases SciELO, PubMed and Science Direct. We included articles published in English, primarily from 2000 to 2011. The key words were Acinetobacter, ...
Published in BMC Pharmacology and Toxicology
Published in African Journal of Pathology and Microbiology
Pseudomonas aeruginosa is a germ of hospitalism responsible for nosocomial infections; it is naturally resistant to many antibiotics and has a high susceptibility to the acquisition of acquiring new resistance. The observation of strains highly resistant to antibiotics, has led us to look for possible alternative therapeutics. This study was a desc...
Published in Journal of Physiology and Biochemistry
Published in Investigational New Drugs
Despite the relevant therapeutic progresses obtained with imatinib, clinical resistance to this drug has emerged and reemerged after cytogenetic remission in a group of patients with chronic myeloid leukemia (CML). Therefore, novel treatment strategies are needed. In this study, we evaluated the anti-CML activity and mechanisms of action of LQB-118...
Published in Cancer Cell International
BackgroundHepatocellular carcinoma (HCC) is a molecular complex tumor with high intrinsic drug resistance. Recent evidence suggests an involvement of the tyrosine kinase pathway in the regulation of ATP-binding cassette protein (ABC-transport protein) mediated multidrug resistance in cancer cells. The aim of this study was to examine whether EGFR i...
Published in Pediatric Rheumatology
Published in Pediatric Rheumatology
Published in Monatsschrift Kinderheilkunde
Tigecyclin ist ein bei Erwachsenen für die Behandlung komplizierter Haut- und Weichgewebsinfektionen sowie komplizierter intraabdomineller Infektionen zugelassenes Reserveantibiotikum. Die Entwicklung hoch resistenter Erreger kann seinen Einsatz jedoch auch bei Kindern, für die keine Zulassung vorliegt, zur Diskussion stellen. Aufgrund seiner Struk...
Published in Archives of Pharmacal Research
