Chen, Yao Sun, Jiaojiao Zhang, Zhiyun Liu, Xiaotong Wang, Qiaozhi Yu, Yang
Published in
BMC Complementary Medicine and Therapies
Background Diabetic retinopathy (DR), one of the most common and severe microvascular complication of diabetes mellitus (DM), is mainly caused by diabetic metabolic disorder. So far, there is no effective treatment for DR. Eriocauli Flos, a traditional Chinese herb, has been used in treating the ophthalmic diseases including DR. However, the active...
Abbasi, Bilal Ahmed Saraf, Devansh Sharma, Trapti Sinha, Robin Singh, Shachee Sood, Shriya Gupta, Pranjay Gupta, Akshat Mishra, Kartik Kumari, Priya
...
Published in
PeerJ
An unusual pneumonia infection, named COVID-19, was reported on December 2019 in China. It was reported to be caused by a novel coronavirus which has infected approximately 220 million people worldwide with a death toll of 4.5 million as of September 2021. This study is focused on finding potential vaccine candidates and designing an in-silico subu...
Adigun, Rasheed A Malan, Frederick P Balogun, Mohammed O October, Natasha
Published in
ChemMedChem
A series of dihydropyrimidinone-based antimalarial compounds were designed and synthesised based on the previously identified amide-based quinoline hybrids which showed good resistance reversal ability against the resistant strain of Plasmodium falciparum. The aromatic ring on the dihydropyrimidinone of the original hits was exchanged for a methyl ...
Manjunathan, Reji Periyaswami, Vijayalakshmi Mitra, Kartik Rosita, Arokiaraj Sherlin Pandya, Medha Selvaraj, Jayaraman Ravi, Lokesh Devarajan, Nalini Doble, Mukesh
Published in
BMC Bioinformatics
Background The Transmembrane Serine Protease 2 (TMPRSS2) of human cell plays a significant role in proteolytic cleavage of SARS-Cov-2 coronavirus spike protein and subsequent priming to the receptor ACE2. Approaching TMPRSS2 as a therapeutic target for the inhibition of SARS-Cov-2 infection is highly promising. Hence, in the present study, we docke...
Jabin, Darakshan Kumar, Ajay
Published in
Journal of Genetic Engineering & Biotechnology
Background Among the most common causes of invasive aspergillosis and acute bronchopulmonary aspergillosis is Aspergillus fumigatus . Transmission with A. fumigatus produces aggressive aspergillosis in allogeneic haematopoietic stem cell transplant recipients, HIV patients, and cancer patients. Asthmatics and cystic fibrosis patients are allergic t...
Mohapatra, Ranjan K. Azam, Mohammad Mohapatra, Pranab K. Sarangi, Ashish K. Abdalla, Mohnad Perekhoda, Lina Yadav, Oval Al-Resayes, Saud I. Jong-Doo, Kim Dhama, Kuldeep
...
Published in
Journal of King Saud University. Science
A compound that could inhibit multiple targets associated with SARS-CoV-2 infection would prove to be a drug of choice against the virus. Human receptor-ACE2, receptor binding domain (RBD) of SARS-CoV-2 S-protein, Papain-like protein of SARS-CoV-2 (PLpro), reverse transcriptase of SARS-CoV-2 (RdRp) were chosen for in silico study. A set of previous...
Pal, Debojyoti Checker, Rahul Kutala, Vijay K. Sandur, Santosh K.
Published in
Molecular Diversity
The coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is affecting human life in an unprecedented manner and has become a global public health emergency. Identification of novel inhibitors of viral infection/replication is the utmost priority to curtail COVID-19 progression. A pre-requisite f...
Umar, Abd. Kakhar Zothantluanga, James H. Aswin, Keerthic Maulana, Saipul Sulaiman Zubair, Muhammad Lalhlenmawia, H. Rudrapal, Mithun Chetia, Dipak
Published in
Structural Chemistry
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected billions and has killed millions to date. Studies are being carried out to find therapeutic molecules that can potentially inhibit the replication of SARS-CoV-2. 3-chymotrypsin-like protease (3CL pro) involved in the polyprotein cleavage process is believed to be the key targ...
Nag, Anish Dhull, Nikhil Gupta, Ashmita
Published in
Molecular Diversity
Tea ( Camellia sinensis L.) is considered as to be one of the most consumed beverages globally and a reservoir of phytochemicals with immense health benefits. Despite numerous advantages, tea compounds lack a robust multi-disease target study. In this work, we presented a unique in silico approach consisting of molecular docking, multivariate stati...
Anowar Hosen, Mohammed Sultana Munia, Nasrin Al-Ghorbani, Mohammed Baashen, Mohammed Almalki, Faisal A. Ben Hadda, Taibi Ali, Ferdausi Mahmud, Shafi Abu Saleh, Md. Laaroussi, Hamid
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Published in
Bioorganic Chemistry
Nucleoside precursors and nucleoside analogs occupy an important place in the treatment of viral respiratory pathologies, especially during the current COVID-19 pandemic. From this perspective, the present study has been designed to explore and evaluate the synthesis and spectral characterisation of 5́- O- (lauroyl) thymidine analogs 2–6 with diffe...
