Location Bias as Emerging Paradigm in GPCR Biology and Drug Discovery
Published in iScience
Pharmacology; Biological Science; Molecular Biology; Cell Biology
Partial Replacement of Nucleosomal DNA with Human FACT Induces Dynamic Exposure and Acetylation of Histone H3 N-Terminal...
Published in iScience
Biochemistry; Molecular Biology; Structural Biology
Matrix Metalloprotease-7 Mediates Nucleolar Assembly and Intra-nucleolar Cleaving p53 in Gefitinib-Resistant Cancer Stem...
Published in iScience
Molecular Biology; Cell Biology; Cancer
Plant Elongator—Protein Complex of Diverse Activities Regulates Growth, Development, and Immune Responses
Published in International Journal of Molecular Sciences
Contrary to the conserved Elongator composition in yeast, animals, and plants, molecular functions and catalytic activities of the complex remain controversial. Elongator was identified as a component of elongating RNA polymerase II holoenzyme in yeast, animals, and plants. Furthermore, it was suggested that Elonagtor facilitates elongation of tran...
Robust Filtering and Noise Suppression in Intragenic miRNA-Mediated Host Regulation
Published in iScience
Biological Sciences; Molecular Biology; Molecular Mechanism of Gene Regulation
Erythropoietin Regulates Transcription and YY1 Dynamics in a Pre-established Chromatin Architecture
Published in iScience
Molecular Biology; Developmental Biology; Genomics
Inhibition of the Activity of Cyclophilin A Impedes Prolactin Receptor-Mediated Signaling, Mammary Tumorigenesis, and Me...
Published in iScience
Medical Biochemistry; Molecular Biology; Cancer
PD-1 Regulates GABAergic Neurotransmission and GABA-Mediated Analgesia and Anesthesia
Published in iScience
Immunology ; Molecular Biology; Neuroscience
Dual Recombining-out System for Spatiotemporal Gene Expression in C. elegans
...Published in iScience
Molecular Biology; Neuroscience; Genetic Engineering
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
...
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide, reaching near fixation in a matter of months. Here we show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, i...
