Khaddour, Karam Khanna, Sangeeta Ansstas, Michael Jakhar, Ishaan Dahiya, Sonika Council, Laurin Ansstas, George
Published in
Cancer immunology, immunotherapy : CII
Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome that involves the production of autoantibodies which can cross-react with retinal epitopes leading to visual symptoms. Autoantibodies can target intracellular proteins, and only a few are directed against membrane proteins. This discrepancy in autoantibody-protein target can transla...
Paumann-Page, Martina Kienzl, Nikolaus F Motwani, Jyoti Bathish, Boushra Paton, Louise N Magon, Nicholas J Sevcnikar, Benjamin Furtmüller, Paul G Traxlmayr, Michael W Obinger, Christian
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Published in
Redox biology
Peroxidasin, a heme peroxidase, has been shown to play a role in cancer progression. mRNA expression has been reported to be upregulated in metastatic melanoma cell lines and connected to the invasive phenotype, but little is known about how peroxidasin acts in cancer cells. We have analyzed peroxidasin protein expression and activity in eight meta...
Rouanet, Jacques Quintana, Mercedes Auzeloux, Philippe Cachin, Florent Degoul, Françoise
Published in
Pharmacology & therapeutics
Cutaneous melanoma arises from proliferating melanocytes, cells specialized in the production of melanin. This property means melanin can be considered as a target for monitoring melanoma patients using nuclear imaging or targeted radionuclide therapy (TRT). Since the 1970s, many researchers have shown that specific molecules can interfere with mel...
Coen, Oliver Corrie, Pippa Marshall, Helen Plummer, Ruth Ottensmeier, Christian Hook, Jane Bell, Sue Sagoo, Gurdeep S. Meads, David Bestall, Janine
...
Published in
BMC Cancer
BackgroundImmunotherapy is revolutionising the treatment of patients diagnosed with melanoma and other cancers. The first immune checkpoint inhibitor, ipilimumab (targeting cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4)), showed a survival advantage over standard chemotherapy. Subsequently the anti-programmed cell death protein 1 (PD-1) antib...
Gorris, Senne Perdaens, Celia Delvaux, Veerle Poorten, Vincent Vander Neyns, Bart Baron, Ilan
Published in
Case Reports in Oncology
Malignant melanoma is a type of cancer that most commonly originates from the skin, less frequently from mucosal surfaces, the eye, or meninges [Annu Rev Pathol. 2014;9(1):239–71]. In 2019, this type of malignancy was the third most frequent cancer to be diagnosed in males and the fifth most in females according to the American Cancer Society and t...
Osofsky, Robin Kamya, Cyril Hanif, Hamza Phuoc, Victor
Published in
Surgical Case Reports
BackgroundMetastatic melanoma to the colon is rarely diagnosed with an incidence of only 0.3% and more than 95% of cases identified post-mortem. Survival for patients with metastatic melanoma to the colon is poor, with 5-year survival rates of 26.5%. Nonetheless, surgical resection of the colonic metastatic melanoma lesions is recommended as it is ...
Villani, Alessia Scalvenzi, Massimiliano Fabbrocini, Gabriella Ocampo-Candiani, Jorge Ocampo-Garza, Sonia Sofía
Published in
Dermatology and Therapy
Even though melanoma represents a small percentage of all cutaneous cancers, it is responsible for most deaths from skin neoplasms. In early stages it can be successfully treated with surgery, but as the disease expands the survival rate drops significantly. For many years the mainstay of treatment for metastatic melanoma was chemotherapeutic agent...
Thyagarajan, Braghadheeswar Bryant, Casey Khanna, Ashish K
Published in
Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine
It is extremely rare for a cardiac tumor to present with coronary-cameral fistulas. A 66-year-old Caucasian male presented with worsening dyspnea and subsequently had a cardiac catheterization for an ST-elevation myocardial infarction, revealing no evidence of coronary artery disease but multiple coronary-cameral fistulas. Venoarterial (VA) extraco...
Vargas-Jiménez, Jose Vargas-Madrigal, Jorge Arias-Mora, Roberto Ulate-Ovares, Diana Solis-Ugalde, Bruno
Published in
Case Reports in Gastroenterology
Pancreatic adenocarcinoma is the most common malignancy of the pancreas; on rare occasions, metastatic tumors are present. Differentiating a primary neoplasm from a metastatic one is important for ensuring adequate treatment for the patient. We present a case of metastatic melanoma to the pancreas. A 60-year-old man presented with a history of weig...
Topin-Ruiz, Solène Mellinger, Adélie Lepeltier, Elise Bourreau, Clara Fouillet, Juliette Riou, Jérémie Jaouen, Gérard Martin, Ludovic Passirani, Catherine Clere, Nicolas
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Published in
International journal of pharmaceutics
Metastatic melanoma is a malignant tumor with a poor prognosis. Recent new therapeutics improved the survival of patients at a metastatic stage. However, the low response rate to immunotherapy, explained in part by resistance to apoptosis, needs to develop new strategies. The ferrocifen family represents promising bioorganometallic molecules for me...
