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Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by...

Voigt, Henning Lemke, Angelika K Mentlein, Rolf Schünke, Michael Kurz, Bodo

Published in Arthritis Research & Therapy

IntroductionLittle is known about factors that induce meniscus damage. Since joint inflammation appears to be a causative factor for meniscal destruction, we investigated the influence of tumor necrosis factor (TNFα) on glycosaminoglycan (GAG) release and aggrecan cleavage in an in vitro model.MethodsMeniscal explant disks (3 mm diameter × 1 mm thi...

NITEGE-Expression in Meniscal Matrix. A New, Immunohistochemical Marker of Meniscal-Tissue Degeneration

Per Knoess Martin Jakobs Mike Otto Gunnar Möllenhoff Manfred Krukemeyer Veit Krenn

Published in Journal of Orthopaedics and Trauma

Background. No marker reflecting the patho-biology of meniscal degeneration (MD) is established so far. NITEGE is a hexapeptide fragments produced when aggrecan is cleaved. Methods. In vitro IL-1 exposition of bovine menisci (n = 4) caused extracellular NITEGE deposits detected by immunofluorescence. A retrospective immunohistochemical analysis of ...

Publication search with Meniscal Degeneration as keyword

Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by...

NITEGE-Expression in Meniscal Matrix. A New, Immunohistochemical Marker of Meniscal-Tissue Degeneration

Publication search
with Meniscal Degeneration as keyword