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with Meniscal Degeneration as keyword
Per Knoess Martin Jakobs Mike Otto Gunnar Möllenhoff Manfred Krukemeyer Veit Krenn
Published in
Journal of Orthopaedics and Trauma
Background. No marker reflecting the patho-biology of meniscal degeneration (MD) is established so far. NITEGE is a hexapeptide fragments produced when aggrecan is cleaved. Methods. In vitro IL-1 exposition of bovine menisci (n = 4) caused extracellular NITEGE deposits detected by immunofluorescence. A retrospective immunohistochemical analysis of ...
Voigt, Henning Lemke, Angelika K Mentlein, Rolf Schünke, Michael Kurz, Bodo
Published in
Arthritis Research & Therapy
IntroductionLittle is known about factors that induce meniscus damage. Since joint inflammation appears to be a causative factor for meniscal destruction, we investigated the influence of tumor necrosis factor (TNFα) on glycosaminoglycan (GAG) release and aggrecan cleavage in an in vitro model.MethodsMeniscal explant disks (3 mm diameter × 1 mm thi...
