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Comparative efficacy of interferon β versus glatiramer acetate for relapsing-remitting multiple sclerosis.

Published in Journal of neurology, neurosurgery, and psychiatry

Interferon β (INFβ) and glatiramer acetate (GA) are widely used in patients with relapsing-remitting multiple sclerosis (RRMS). However, it is still unclear whether they have different efficacy. We performed a systematic search of head-to-head trials for gaining objective reliable data to compare the two drugs, using the Cochrane Collaboration meth...

Lethal arrhythmia due to fingolimod, a S1P receptor modulator: are we overestimating or underestimating?

Published in Journal of neurology, neurosurgery, and psychiatry

Ventricular tachycardia on chronic fingolimod treatment for multiple sclerosis.

Published in Journal of neurology, neurosurgery, and psychiatry

MRI pattern in asymptomatic natalizumab-associated PML.

Published in Journal of neurology, neurosurgery, and psychiatry

Asymptomatic natalizumab-associated PML manifestations on MRI show a rather localised disease, frequently located in the frontal lobes, affecting the cortical grey matter and adjacent juxtacortical white matter. Awareness of this lesion pattern facilitates an earlier diagnosis of natalizumab-associated PML in an asymptomatic stage associated with a...

Helicobacter pylori infection might prove the hygiene hypothesis in multiple sclerosis.

Published in Journal of neurology, neurosurgery, and psychiatry

The natural history of early versus late disability accumulation in primary progressive MS.

Published in Journal of neurology, neurosurgery, and psychiatry

Age at disease onset is the most important predictor of disability accumulation in PPMS. Bilateral motor onset symptoms were associated with quicker disease progression. In contrast to RRMS, we found no evidence for distinct phases of disability accumulation in PPMS. Disability accumulation in PPMS appears to be affected by the same factors through...

Spinal cord grey matter abnormalities are associated with secondary progression and physical disability in multiple scle...

Published in Journal of neurology, neurosurgery, and psychiatry

The study findings suggest that pathological involvement of the spinal cord GM contributes significantly to physical disability in relapse-onset MS and SPMS in particular.

Helicobacter pylori infection as a protective factor against multiple sclerosis risk in females.

Published in Journal of neurology, neurosurgery, and psychiatry

Our results could reflect a protective role of H. pylori in the disease development. However, it may be that H. pylori infection is a surrogate marker for the 'hygiene hypothesis', a theory which postulates that early life infections are essential to prime the immune system and thus prevent allergic and autoimmune conditions later in life. The fact...

Earlier and more frequent diagnosis of multiple sclerosis using the McDonald criteria.

Published in Journal of neurology, neurosurgery, and psychiatry

DIR-visible grey matter lesions and atrophy in multiple sclerosis: partners in crime?

BACKGROUND: The extent and clinical relevance of grey matter (GM) pathology in multiple sclerosis (MS) are increasingly recognised. GM pathology may present as focal lesions, which can be visualised using double inversion recovery (DIR) MRI, or as diffuse pathology, which can manifest as atrophy. It is, however, unclear whether the diffuse atrophy ...