Ofori, Emmanuel Owusu Bin Alhassan, Baba Alhaji Ayabilah, Edwina Ayaaba Maison, Patrick Opoku Manu Asante-Asamani, Alvin Atawura, Henry Rahman, Ganiyu Adebisi Akakpo, Patrick Kafui Imbeah, Emmanuel Gustav Ofori, Prince Wilson
...
Published in
African Journal of Urology
BackgroundRenal cell carcinoma (RCC) is a heterogeneous group of malignant epithelial tumors of the kidney. It accounts for more than 90% of all kidney cancers. However, papillary RCC is the second most common histologic subtype representing 10–15% of all RCCs. The mean age of presentation for papillary RCC ranges between 59 and 63 years but more i...
Oka, Yoshito Takano, Shigetsugu Kouchi, Yusuke Furukawa, Katsunori Takayashiki, Tsukasa Kuboki, Satoshi Suzuki, Daisuke Sakai, Nozomu Kagawa, Shingo Hosokawa, Isamu
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Published in
BMC Gastroenterology
BackgroundPancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the brain; therefore, the features of brain metastasis of PDAC are still unknown. We encountered simultaneous metastases to the brain and lung in a PDAC patient after curative surgery.Case presentationA 68-year-old man with PDAC in the tail of the pancreas underwent distal pan...
Muroya, Daisuke Sato, Toshihiro Sakai, Hisamune Hisaka, Toru Akagi, Yoshito Okuda, Koji
Published in
International journal of surgery case reports
Spontaneous regression of hepatocellular carcinoma (HCC) is a rare condition. However, although there have been multiple reports of spontaneous regression, the definitive pathogenic mechanism of this phenomenon is still unclear. We encountered a case of a 78-year-old man who was undergoing dialysis for end-stage kidney disease with hepatitis C viru...
Horiguchi, Hiroyuki Tsujimoto, Hironori Shinomiya, Nariyoshi Matsumoto, Yusuke Sugasawa, Hidekazu Yamori, Takao Miyazaki, Hiromi Saitoh, Daizoh Kishi, Yoji Ueno, Hideki
...
Published in
Anticancer research
Local and systemic inflammations are associated with negative long-term outcomes; however, their precise mechanism of action remains unclear. We previously demonstrated that hepatocyte growth factor (HGF)/c-Met signaling contributed to the enhancement of liver metastasis associated with peritonitis model. The aim of this study is to investigate the...
Kawanishi, Yasuhiro Kuwahara, Michio Utsunomiya, Masato Ishida, Nobuko Ishikawa, Yoichi Hiroi, Makoto Akimori, Toyokazu
Published in
Clinical journal of gastroenterology
Lenvatinib is an inhibitor of tyrosine kinases, such as vascular endothelial growth factor receptor and fibroblast growth factor receptor, and was first approved for use in thyroid cancer in 2015 in Japan. Additional approval was given in March 2018 for its use as a first-line treatment for advanced or unresectable hepatocellular carcinoma. Herein,...
Fujino, Rika Masuoka, Yoshihito Mashiko, Taro Nakano, Akira Hirabayashi, Kenichi Nakagohri, Toshio
Published in
World Journal of Surgical Oncology
BackgroundIntraductal papillary neoplasm of the bile duct (IPNB) is considered a pre-cancerous biliary lesion and/or an early cancer lesion, although its classification remains unclear. The 2019 revised edition of the World Health Organization Classification of Tumors of the Digestive System proposed type 1 and type 2 as new classification categori...
Zhang, Xueqing Huang, Yamei Song, Heliang Canup, Brandon S B Gou, Shuangquan She, Zhigang Dai, Fangyin Ke, Bowen Xiao, Bo
Published in
Journal of controlled release : official journal of the Controlled Release Society
Lung metastasis of breast cancer is a leading cause of cancer-related death in women. Herein, we attempted to simultaneously inhibit the growth and lung metastasis of breast cancer by delivering quercetin (QU) using LyP-1-functionalized regenerated silk fibroin-based nanoparticles (NPs). The generated LyP-1-QU-NPs had a desirable diameter (203.2 nm...
Pham, Kien Huynh, Do Le, Le Delitto, Daniel Yang, Lei Huang, Jing Kang, Yibin Steinberg, Michael B Li, Jieliang Zhang, Lanjing
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Published in
Cancer letters
Young women represent a target of E-cigarette (E-cig) companies, raising concern for potential connections with breast cancer (BC) that have not yet been elucidated. We hypothesized that E-cig promotes BC development and lung metastasis possibly through BC-monocyte/tumor-associated macrophage (TAM) crosstalk via CCL5 and V-CAM-1 axes. We demonstrat...
Stansel, Tomoko Wickline, Samuel A Pan, Hua
Published in
Journal of cancer science and clinical therapeutics
Although novel therapeutic regimens for melanoma continue to emerge, the best current clinical response rate is still less than 60%. Moreover, antimelanoma treatments contribute to toxicities in other vital organs. In this study, we elucidate the therapeutic advantages of siRNA targeting melanoma NF-κB canonical signaling pathway with a peptide-bas...
Sekiguchi, Kumiko Matsutani, Takeshi Nomura, Tsutomu Hagiwara, Nobutoshi Matsuda, Akihisa Hanawa, Hidetsugu Mishima, Keisuke Taniai, Nobuhiko Ohashi, Ryuji Yoshida, Hiroshi
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Published in
Surgical Case Reports
BackgroundSolitary pulmonary metastasis from esophageal basaloid squamous cell carcinoma (BSCC) components is an extremely rare recurrence of esophageal squamous cell carcinoma (SCC).Case presentationA 68-year-old Japanese woman was found to have a suspected malignant mass, approximately 2 cm in diameter, in her left lower pulmonary lobe, at 66 mon...
