Guaragna, Regina M. Trugo, Luiz Borojevic, Radovan
Published in
Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Connective tissue cells of liver parenchyma (perisinusoidal myofibroblasts) can be induced to express the lipocyte (Ito cell) phenotype. We have studied phospholipid synthesis and phosphate incorporation during this in vitro conversion, induced by insulin and/or indomethacin, in the established murine cell line GRX. Phospholipid synthesis, measured...
Liu, C H Liu, C Liu, P Xu, L M
Published in
World journal of gastroenterology
To investigate the mechanisms of anti-liver fibrosis actions of Fuzheng Huayu (FZHY) decoction, which acts to strengthen the body's resistance and promote blood circulation. Ito cells were isolated from rats and cultured. Serum samples were collected from healthy (normal) rats after administration of FZHY decoction and added to the subcultured cell...
Yamada, Masahiko Fukuda, Yoshihide Nakano, Isao Katano, Yoshiaki Takamatsu, Junki Hayakawa, Tetsuo
Published in
Acta Haematologica
We measured serum type III procollagen peptide, type IV collagen (IV-C), and hyaluronan (HA) in 36 hemophiliacs with hepatitis C virus (HCV)-related chronic liver disease. We also measured these markers in 19 interferon (IFN)-treated patients before and after a 6-month course of IFN-α. The serum concentrations of IV-C and HA were correlated with th...
Hayasaka, Akira Saisho, Hiromitsu
Published in
Digestion
Nan, Ji -Xing Park, Eun -Jeon Lee, Sung Hee Park, Pil -hoon Kim, Ji Young Ko, Geonil Sohn, Dong Hwan
Published in
Archives of Pharmacal Research
We examined the antifibrotic effect of a methanol extract fromStephania tetrandra (ST) on experimental liver fibrosis. Liver fibrosis was induced by bile duct ligation and scission (BDL/S) in rats. In BDL/S rats, activity levels of aspartate transaminase (AST), alanine transaminse (ALT), alkaline phosphatase (ALP), concentration of total bilirubin ...
Kobayashi, Hiroyuki Horikoshi, Kentaro Yamataka, Atsuyuki Lane, Geoffrey J. Yamamoto, Masahiro Miyano, Takeshi
Published in
Pediatric Surgery International
Inchin-ko-to (ICKT) prevents Fas-mediated liver injury. This study evaluates the effect of ICKT on conventional markers of liver function (LF) and liver fibrosis in 18 postoperative biliary atresia (BA) patients aged 3 to 23 years with elevated glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), γ-glutamyl transpeptidase (...
Yoshiji, Hitoshi Kuriyama, Shigeki Fukui, Hiroshi
Published in
Tumor Biology
The renin-angiotensin system (RAS) is frequently activated in patients with chronic liver diseases. Angiotensin-II (AT-II), which is produced by angiotensin-converting enzyme (ACE), has many physiological effects, including strong pro-angiogenic activity. AT-II induces the potent angiogenic factor, vascular endothelial growth factor (VEGF). Recent ...
Freeman, Thomas L. Kharbanda, Kusum K. Tuma, Dean J. Mailliard, Mark E.
Published in
Biochemical Pharmacology
The increased deposition of extracellular matrix by hepatic stellate cells following liver injury, in a process known as activation, is considered a key mechanism for increased collagen content of liver during the development of liver fibrosis. We report that N-(methylamino)isobutyric acid (MeAIB), a specific inhibitor of System A-mediated amino ac...
Gardi, Concetta Arezzini, Beatrice Fortino, Vittoria Comporti, Mario
Published in
Biochemical Pharmacology
Various studies on hepatic fibrosis occurring in iron overload suggest that excess of tissue iron may be involved in the stimulation of collagen synthesis. Anyway, up to date, direct evidence on the role of iron in hepatic fibrosis is lacking. Moreover, it is not clear whether iron acts as direct initiator of fibrogenesis or as mediator of hepatoce...
Guangjin, Shen Mingdao, Jiao Qiyang, Li Hui, Xu Jiangming, Han Xiaomei, Yin
Published in
Acta Tropica
Thirty-eight cases clinically diagnosed as advanced schistosomiaisis were subject to splenectomy in Dongzhi County Special Hospital for Schistosomiasis because of portal hypertension, splenomegaly and/or hypersplenism. Liver biopsy was undertaken in all cases during surgical intervention. Before operation, ultrasonography on the liver and spleen wa...
