Park, Hyo Eun Lee, Heesun Choi, Su-Yeon Kim, Hua Sun Chung, Goh Eun
Published in
Scientific Reports
Previous epidemiological studies focusing on the association between liver disease and atrial fibrillation (AF) show interesting but inconsistent findings. Patients with liver disease have a higher AF risk; however, it is unknown whether the liver fibrosis index can predict AF risk. The medical records of a healthy population undergoing routine hea...
Cao, Xi Shang, Qing-Hua Chi, Xiao-Ling Zhang, Wei Xiao, Huan-Ming Sun, Mi-Mi Chen, Gang An, Yong Lv, Chun-Lei Wang, Lin
...
Published in
World Journal of Gastroenterology
BACKGROUND Hepatitis B virus (HBV) infection is the primary cause of hepatitis with chronic HBV infection, which may develop into liver fibrosis, cirrhosis and hepatocellular carcinoma. Detection of early-stage fibrosis related to HBV infection is of great clinical significance to block the progression of liver lesion. Direct liver biopsy is regard...
Dufton, Neil P. Peghaire, Claire R. Osuna-Almagro, Lourdes Raimondi, Claudio Kalna, Viktoria Chauhan, Abhishek Webb, Gwilym Yang, Youwen Birdsey, Graeme M. Lalor, Patricia
...
Published in
Nature Communications
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Shao, Tuo Chen, Zhen Belov, Vasily Wang, Xiaohong Rwema, Steve H Kumar, Viksit Fu, Hualong Deng, Xiaoyun Rong, Jian Yu, Qingzhen
...
Published in
Journal of hepatology
The vitronectin receptor integrin alpha v beta 3 (αvβ3) drives fibrogenic activation of hepatic stellate cells (HSC). Molecular imaging targeting the integrin αvβ3 could provide a non-invasive method for evaluating the expression and the function of the integrin αvβ3 on activated HSCs (aHSCs) in the injured liver. In this study, we sought to compar...
Hoffmann, Céline Djerir, Nour El Houda Danckaert, Anne Fernandes, Julien Roux, Pascal Charrueau, Christine Lachagès, Anne-Marie Charlotte, Frédéric Brocheriou, Isabelle Clément, Karine
...
Published in
Scientific Reports
Hepatic fibrosis is a major consequence of chronic liver disease such as non-alcoholic steatohepatitis which is undergoing a dramatic evolution given the obesity progression worldwide, and has no treatment to date. Hepatic stellate cells (HSCs) play a key role in the fibrosis process, because in chronic liver damage, they transdifferentiate from a ...
Maeda, Daichi Sakane, Kazushi Ito, Takahide Kanzaki, Yumiko Sohmiya, Koichi Hoshiga, Masaaki
Published in
Heart and vessels
The fibrosis-4 index (FIB-4 index) is a marker of liver fibrosis. It has been reported that the FIB-4 index in compensated phase is associated with estimated right-sided filling pressure and poor prognosis in patients with heart failure. However, the relationship with invasively obtained right-sided cardiac pressures has been unclear. Hemodynamic s...
Ishii, Masatsugu Itano, Osamu Shinoda, Masahiro Kitago, Minoru Abe, Yuta Hibi, Taizo Yagi, Hiroshi Takeuchi, Ayano Tsujikawa, Hanako Abe, Tokiya
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Published in
World Journal of Gastroenterology
BACKGROUND Liver resection is an effective treatment for benign and malignant liver tumors. However, a method for preoperative evaluation of hepatic reserve has not yet been established. Previously reported assessments of preoperative hepatic reserve focused only on liver failure in the early postoperative period and did not consider the long-term ...
Cai, Xuanyan Wang, Jiajia Wang, Jincheng Zhou, Qian Yang, Bo He, Qiaojun Weng, Qinjie
Published in
Pharmacological research
Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to date. Activated hepatic stellate cells (HSCs) are the major cellular source of matrix-producing myofibroblasts, playing a central role in the initiation and p...
Zhang, Kun Shi, Zhemin Zhang, Mengxia Dong, Xueyi Zheng, Lina Li, Guantong Han, Xiaohui Yao, Zhi Han, Tao Hong, Wei
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Published in
Cell Death & Disease
Hepatic fibrosis is a common pathological consequence of a sustained wound healing response to continuous liver injury, characterized by increased production and accumulation of extracellular matrix. If unresolved, the fibrotic process results in organ failure, and eventually death after the development of cirrhosis. It has been suggested that macr...
Xu, Nan Xie, Qinxiu Li, Jiang Gao, Yufeng Li, Xu
Published in
The Journal of International Medical Research
Objective This study was performed to clarify the influence of nonalcoholic fatty liver disease (NAFLD) on liver stiffness measurement (LSM) and establish a new diagnostic model. Methods A retrospective cohort of 601 patients with chronic hepatitis B (CHB) was enrolled as the derivation group, and a prospective cohort of 30 patients with concurrent...
