Deng, Jia-Yi Gou, Qing Yang, Lingling Chen, Zhi-Hong Yang, Ming-Yi Yang, Xiao-Rong Yan, Hong-Hong Wei, Xue-Wu Liu, Jia-Qi Su, Jian
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Published in
Journal for Immunotherapy of Cancer
Background The liver is a frequent site of metastases and liver metastases (LM) correlate with diminished immunotherapy efficacy in non-small cell lung cancer (NSCLC). This study aimed to analyze whether tumor response to immunotherapy differs between pulmonary lesions (PL) and LM in NSCLC and to explore potential mechanisms through multiomics anal...
Wang, Zhijun Kim, So Tu, Wei Kim, Jieun Xu, Alexander Yang, Yoon Matsuda, Michitaka Reolizo, Lien Tsuchiya, Takashi Billet, Sandrine
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Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). Fatty liver promotes liver metastasis, but the underlying mechanism remains unclear. We demonstrated that hepatocyte-derived extracellular vesicles (EVs) in fatty liver enhanced the progression of CRC liver metastasis by promoting oncogenic Yes-associated protein (...
Harrison, Stephen A Loomba, Rohit Dubourg, Julie Ratziu, Vlad Noureddin, Mazen
Nonalcoholic fatty liver disease consists of a spectrum starting from nonalcoholic fatty liver disease that may progress to nonalcoholic steatohepatitis (NASH), which can lead to fibrosis, cirrhosis, hepatocellular carcinoma, or even liver failure. The prevalence of NASH has increased in parallel with the rising rate of obesity and type 2 diabetes....
Kim, Nicole J Vutien, Philip Cleveland, Erin Cravero, Anne Ioannou, George N
Published in
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Hepatitis C virus (HCV) eradication with direct-acting antivirals reduces hepatocellular carcinoma (HCC) risk. Pooled HCC incidence rates by cirrhosis status and fibrosis stage have not been estimated using meta-analysis. We searched PubMed, Web of Science, Embase, and Cochrane Library from January 1, 2014 to December 31, 2020 to identify studies a...
Weng, Jialei Liu, Shaoqing Zhou, Qiang Xu, Wenxin Xu, Minghao Gao, Dongmei Shen, Yinghao Yi, Yong Shi, Yi Dong, Qiongzhu
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Published in
Journal for immunotherapy of cancer
Hepatocellular carcinoma (HCC) is a malignancy with limited treatment options and poor prognosis. Macrophages are enriched in the HCC microenvironment and have a significant impact on disease progression and therapy efficacy. We aim to identify critical macrophages subsets involved in HCC development. Macrophage-specific marker genes were identifie...
Hughes, Katherine Radakovic, Milorad Gorman, Frank Malinowska, Beata Cullen, John M
The cadaver and viscera of a mature female sheep (Ovis aries) underwent routine abattoir meat inspection. The liver was expanded by an infiltrative neoplastic mass comprising multifocal to coalescing, well-demarcated, pink to white-yellow nodules, up to 25 mm in diameter. An unencapsulated, moderately densely cellular, infiltrative neoplasm was pre...
Pan, Banglun Chen, Zhanfei Zhang, Xiaoxia Wang, Zengbin Yao, Yuxin Wu, Xiaoxuan Qiu, Jiacheng Lin, Hua Yu, Liumin Tu, Haijian
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Published in
Journal for Immunotherapy of Cancer
Background 2,5-dimethylcelecoxib (DMC), a derivative of celecoxib, is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1). Our previous studies have demonstrated that DMC inhibits the expression of programmed death-ligand 1 on hepatocellular carcinoma (HCC) cells to prevent tumor progression. However, the effect and mechanism of DMC on ...
Hong, Cheng Chernyak, Victoria Choi, Jin-Young Lee, Sonia Potu, Chetan Delgado, Timoteo Wolfson, Tanya Gamst, Anthony Birnbaum, Jason Kampalath, Rony
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Background Various limitations have impacted research evaluating reader agreement for Liver Imaging Reporting and Data System (LI-RADS). Purpose To assess reader agreement of LI-RADS in an international multicenter multireader setting using scrollable images. Materials and Methods This retrospective study used deidentified clinical multiphase CT an...
Lu, Xinjun Deng, Shanshan Xu, Jiejie Green, Benjamin L Zhang, Honghua Cui, Guofei Zhou, Yi Zhang, Yi Xu, Hongwei Zhang, Fapeng
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Many patients with hepatocellular carcinoma (HCC) do not respond to the first-line immune checkpoint inhibitor treatment. Immunization with effective cancer vaccines is an attractive alternative approach to immunotherapy. However, its efficacy remains insufficiently evaluated in preclinical studies. Here, we investigated HCC-associated self/tumor a...
Hu, Ying Setayesh, Tahereh Vaziri, Farzam Wu, Xuesong Hwang, Samuel T Chen, Xin Wan, Yu-Jui Yvonne
MicroRNA-22 (miR-22) can be induced by beneficial metabolites that have metabolic and immune effects, including retinoic acids, bile acids, vitamin D3, and short-chain fatty acids. The tumor suppressor effects of miR-22 have been suggested, but whether miR-22 treats orthotopic hepatocellular carcinoma (HCC) is not established. The role of miR-22 in...
