Boros, Sandor Bindels, René J. M. Hoenderop, Joost G. J.
Published in
Pflügers Archiv - European Journal of Physiology
The kidney plays a crucial role in the maintenance of the body calcium (Ca2+) balance. Ca2+ is an essential ion in all organisms and participates in a large variety of structural and functional processes. In mammals, active tubular Ca2+ reabsorption is restricted to the distal part of the nephron, i.e., the late distal convoluted (DCT2) and the con...
Taylor, Jeremy G. Bushinsky, David A.
Published in
Blood Purification
Calcium and phosphorus homeostasis relies on a complex, tightly regulated system involving many ions and hormones. The regulation of calcium and phosphorus is controlled by the actions of these ions and hormones on the intestine, kidneys and bone. Disturbances in the serum level of calcium and/or phosphorus can lead to significant pathology, includ...
Kuro-o, Makoto
Published in
Biochimica et biophysica acta
The klotho gene encodes a single-pass transmembrane protein that forms a complex with multiple fibroblast growth factor (FGF) receptors and functions as an obligatory co-receptor for FGF23, a bone-derived hormone that induces negative phosphate balance. Defects in either Klotho or Fgf23 gene expression cause not only phosphate retention but also a ...
Yu, Jie Deng, Mengyang Zhao, Jinghong Huang, Lan
Published in
Biochemical and Biophysical Research Communications
Chronic renal failure (CRF) markedly accelerates the development of atherosclerosis, but the pathogenesis of uremic atherosclerosis remains to be elucidated. The klotho gene, predominantly expressed in the kidney, plays a key role in regulating aging and the development of age-related diseases in mammals. A loss of klotho results in multiple aging-...
DA SILVA, Patrick PRIE, Dominique
FR
Wang, Yuhong Sun, Zhongjie
Published in
Ageing research reviews
Klotho is a new anti-aging gene. Genetic mutation of klotho causes multiple premature aging-like phenotypes and strikingly shortens lifespan. Overexpression of the klotho gene in mice suppresses aging and extends lifespan which may involve the mechanism of suppression of insulin signaling and oxidant stress. Klotho functions as a cofactor/corecepto...
DA SILVA, Patrick PRIE, Dominique
PARIS7-Xavier Bichat (751182101) / Sudoc / Sudoc / France / FR
Krajisnik, Tijana
Fibroblast growth factor-23 (FGF23) is a novel, bone-produced hormone that regulates renal phosphate (Pi) reabsorption and calcitriol metabolism. Disorders of mineral and bone metabolism, such as autosomal dominant hypophosphatemic rickets (ADHR) and hyperostosis-hyperphosphatemia syndrome (HHS), witness the importance of well-balanced serum levels...
Garringer, Holly J Malekpour, Mahdi Esteghamat, Fatemehsadat Mortazavi, Seyed M J Davis, Siobhan I Farrow, Emily G Yu, Xijie Arking, Dan E Dietz, Harry C White, Kenneth E
...
Published in
American journal of physiology. Endocrinology and metabolism
Fibroblast growth factor 23 (FGF23) is a hormone required for normal renal phosphate reabsorption. FGF23 gain-of-function mutations result in autosomal dominant hypophosphatemic rickets (ADHR), and FGF23 loss-of-function mutations cause familial hyperphosphatemic tumoral calcinosis (TC). In this study, we identified a novel recessive FGF23 TC mutat...
Zhou, Xin J. Saxena, Ramesh Liu, Zhihong Vaziri, N. D. Silva, Fred G.
Published in
International Urology and Nephrology
Kidneys are significantly affected by profound anatomic and functional changes with senescence. These changes lead to decline in glomerular filtration rate, decreased urinary concentrating and diluting ability, diminished urinary acidification, and impaired potassium clearance, to list a few. Such changes make the elderly prone to drug toxicity and...