Lee, Sanghoon Jung, Min Hee Song, Kilyoung Jin, Jun-Xue Taweechaipaisankul, Anukul Kim, Geon A. Oh, Hyun Ju Koo, Ok Jae Park, Se Chang Lee, Byeong Chun
...
Published in
BMC Biotechnology
BackgroundSmall animals that show a deficiency in klotho exhibit extremely shortened life span with multiple aging-like phenotypes. However, limited information is available on the function of klotho in large animals such as pigs.ResultsIn an attempt to produce klotho knockout pigs, an sgRNA specific for klotho (targeting exon 3) was designed and C...
Panizo, Sara Martínez-Arias, Laura Alonso-Montes, Cristina Cannata, Pablo Martín-Carro, Beatriz Fernández-Martín, José L. Naves-Díaz, Manuel Carrillo-López, Natalia Cannata-Andía, Jorge B.
Published in
International Journal of Molecular Sciences
Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix as a response to different types of tissue injuries, which leads to organ dysfunction. The process can be initiated by multiple and different stimuli and pathogenic factors which trigger the cascade of reparation converging in molecular signals responsible ...
da Paz Oliveira, Giuliano Elias, Rosilene Motta Peres Fernandes, Gustavo Bruniera Moyses, Rosa Tufik, Sergio Bichuetti, Denis Bernardi Coelho, Fernando Morgadinho Santos
Published in
Sleep medicine
to explore the status of concentration of klotho and fibroblast growth factor 23 (FGF23) in cerebrospinal fluid (CSF) of patients with narcolepsy. 59 patients with narcolepsy and 17 control individuals were enrolled. We used radioimmunoassay, human klotho enzyme-linked immunosorbent assay (ELISA), human intact FGF23 ELISA and spectrophotometry to m...
Ortiz, Alberto
Published in
Clinical Kidney Journal
Six years ago, a comprehensive review by the EURECA-m working group of the ERA-EDTA thoroughly addressed the drivers of mortality in patients with end-stage kidney disease. Not unexpectedly, the key global driver of early death in these patients was the lack of access to kidney replacement therapy. However, and contrary to the expectations of non-n...
Xu, Zhuofan Zheng, Shaoxin Feng, Xiaoqian Cai, Chengzhe Ye, Xianqu Liu, Pingfang
Published in
Experimental and Therapeutic Medicine
The aim of the present study was to investigate the effects and mechanisms of the Klotho gene in oxidative stress injury after myocardial infarction. Sprague-Dawley rats were divided into five groups (sham, model, pDC316, LY294002, and pDC316-Klotho). Subsequently, the superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) concent...
Yu, Shasha Yang, Hongmei Guo, Xiaofan Sun, Yingxian
Published in
Molecular Medicine Reports
Hyperglycemia is known to lead to cardiac injury and inflammation through the reactive oxygen species (ROS)-Toll-like receptor 4 (TLR4)-necroptosis pathway. Similarly, angiotensin II (Ang II) activates the TLR4-nuclear factor κB (NF-κB) p65 pathway, while the protein Klotho is known to inhibit this pathway, protecting cardiac cells from Ang II-indu...
Kim, Eui Hyun Taweechaipaisankul, Anukul Ridlo, Muhammad Rosyid Kim, Geon A Lee, Byeong Chun
Published in
Aging (Albany NY)
Klotho protein is well-known as an anti-aging agent, however, several studies have suggested that Klotho protein also increases antioxidant activity and the reproductive system, as Klotho protein is closely associated with Wnt signaling. The objective of our study was to investigate the enhancement of porcine oocyte in vitro maturation via the Klot...
Kim, Da Yeon Lee, Minyoung Kim, Eun Ju
Published in
Molecular Medicine Reports
While radiation nephropathy is a major problem associated with radiotherapy, the exact mechanisms underlying its pathogenesis and the mediators involved in kidney deterioration remain to be elucidated. In view of the finding that senescence is typically increased post-irradiation, the present study examined whether ionizing radiation may cause kidn...
Daneshgar, Nastaran Dai, Dao-Fu
Published in
Aging (Albany NY)
Shafie, Anahid Rahimi, Ahmad Mustafa Ahmadi, Iraj Nabavizadeh, Fatemeh Ranjbaran, Mina Ashabi, Ghorbangol
Published in
Nutrition & Metabolism
BackgroundIn the current study, our specific aim was to characterize the Klotho protein and expression levels in the hippocampus and prefrontal cortex of old rats treated with different diets (high-fat, high-protein, low-calorie, high-protein and low-calorie).MethodsRats were treated with high-fat, high-protein, low-calorie, low-calorie high-protei...