Kumwenda, Geoffrey P Sugawara, Yo Abe, Ryuichiro Akeda, Yukihiro Kasambara, Watipaso Chizani, Kenneth Takeuchi, Dan Sakamoto, Noriko Tomono, Kazunori Hamada, Shigeyuki
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Published in
Journal of medical microbiology
Purpose. Carbapenemase-producing Enterobacteriaceae (CPE) have become a global concern and a serious threat to human health due to their resistance to multiple antibiotics. In this study, we identified and characterized CPE for the first time in Malawi, southeastern Africa.Methodology. We investigated the possible presence of carbapenemases among a...
Papagiannitsis, Costas C Bitar, Ibrahim Malli, Ergina Tsilipounidaki, Katerina Hrabak, Jaroslav Petinaki, Efthimia
Published in
Journal of global antimicrobial resistance
This study describes the characterisation of type 2 IncC plasmids pC-Ec20-KPC and pC-Ec2-KPC, carrying theblaKPC-2 gene, from two multiresistant Escherichia coli recovered in University Hospital of Larissa (Greece) in 2018. E. coli strains Ec-2Lar and Ec-20Lar were recovered from rectal swabs of two patients during monthly surveillance cultures. Tr...
Ferrari, Carolina Corbella, Marta Gaiarsa, Stefano Comandatore, Francesco Scaltriti, Erika Bandi, Claudio Cambieri, Patrizia Marone, Piero Sassera, Davide
Published in
Frontiers in microbiology
The circulation of carbapenem-resistant Klebsiella pneumoniae (CRKP) is a significant problem worldwide. In this work we characterize the isolates and reconstruct the spread of a multi-clone epidemic event that occurred in an Intensive Care Unit in a hospital in Northern Italy. The event took place from August 2015 to May 2016 and involved 23 patie...
Mueller, Linda Masseron, Amandine Prod’Hom, Guy Galperine, Tatiana Greub, Gilbert Poirel, Laurent Nordmann, Patrice
Published in
Antimicrobial Agents and Chemotherapy
A novel KPC variant, KPC-41, was identified in a Klebsiella pneumoniae clinical isolate from Switzerland. This β-lactamase possessed a 3-amino-acid insertion (Pro-Asn-Lys) located between amino acids 269 and 270 compared to the KPC-3 amino acid sequence. Cloning and expression of the bla KPC-41 gene in Escherichia coli , followed by determination o...
Baeza, L Lucena Pfennigwerth, N Greissl, C Göttig, S Saleh, A Stelzer, Y Gatermann, S G Hamprecht, A
Published in
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
The aim of this study was to evaluate the performance of five different carbapenemase tests and to develop an algorithm which will permit the detection of most common and rare carbapenemases in routine microbiology laboratories. The immunochromatographic tests CARBA-5 (NG), RESIST-4 O.K.N.V. (Coris), the colorimetric β-CARBA (BioRad), a newly devel...
Firmo, Elza Ferreira Beltrão, Elizabeth Maria Bispo Silva, Felipe Rogério Ferreira da Alves, Luis Carlos Brayner, Fábio André Veras, Dyana Leal Lopes, Ana Catarina Souza
Published in
Journal of global antimicrobial resistance
Carbapenemase-producing Enterobacterales are frequently involved in healthcare-associated infections worldwide. The objectives of this study were to investigate (i) the frequency of the main genes encoding carbapenemases, 16S rRNA methylases and aminoglycoside-modifying enzymes (AMEs) as well as the mcr gene and (ii) the clonal relationship of ente...
Karukes, E Benito, M Iocco, F Trotta, R Geringer-Sameth, A
We develop a novel Bayesian methodology aimed at reliably and precisely inferring the distribution of dark matter within the Milky Way using rotation curve data. We identify a subset of the available rotation curve tracers that are mutually consistent with each other, thus eliminating data sets that might suffer from systematic bias. We investigate...
Pasquale, Valentina Dugnani, Erica Liberati, Daniela Marra, Paolo Citro, Antonio Canu, Tamara Policardi, Martina Valla, Libera Esposito, Antonio Piemonti, Lorenzo
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Published in
Acta diabetologica
More than 40% of pancreatic ductal adenocarcinoma (PDAC) patients have glucose intolerance or diabetes. The association has led to two hypotheses: PDAC causes diabetes or diabetes shares risk factors for the development of PDAC. In order to elucidate the relationship between diabetes and PDAC, we investigated the glucose metabolism during tumorigen...
Lee, Yu-Lin Lu, Min-Chi Shao, Pei-Lan Lu, Po-Liang Chen, Yen-Hsu Cheng, Shu-Hsing Ko, Wen-Chien Lin, Chi-Ying Wu, Ting-Shu Yen, Muh-Yong
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Published in
International journal of antimicrobial agents
Multicentre surveillance of antimicrobial susceptibility of clinically important Gram-negative bacteria (GNB) from 16 Taiwanese hospitals was performed. Escherichia coli (n = 398), Klebsiella pneumoniae (n = 346), Pseudomonas aeruginosa (n = 252) and Acinetobacter baumannii complex (ABC) (n = 188) bloodstream isolates, non-typhoidal Salmonella (n =...
Smith, Kenneth P Dowgiallo, Matthew G Chiaraviglio, Lucius Parvatkar, Prakash Kim, Chungsik Manetsch, Roman Kirby, James E
Published in
SLAS discovery : advancing life sciences R & D
Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging antimicrobial resistance threat for which few if any therapeutic options remain. Identification of new agents that either inhibit CRE or restore activity of existing antimicrobials is highly desirable. Therefore, a high-throughput screen of 182,427 commercially available compounds was us...
