Incampo, Francesca Carrieri, Cosimo Galasso, Rita Marino, Renato Ettorre, Cosimo P. Semeraro, Nicola Colucci, Mario
Published in
Thrombosis Research
Background and ObjectiveTreatment with vitamin K antagonists (VKA) reduces fibrinolytic resistance through the inhibition of thrombin-mediated activation of thrombin activatable fibrinolysis inhibitor (TAFI). Because low-molecular weight heparin (LMWH) is co-administered with VKA during initiation of anticoagulant treatment, we evaluated the effect...
Grzymala-Lubanski, Bartosz Labaf, Ashkan Englund, Erling Svensson, Peter J. Själander, Anders
Published in
Thrombosis Research
IntroductionEvery year about 2500 patients in Sweden undergo surgery due to heart valve disease. A mechanical heart valve prosthesis causes risk of thromboembolic stroke or thrombus formation in the valve while anticoagulant treatment increases the risk of bleeding. Treatment quality with warfarin is crucial for patients with mechanical valve prost...
Meesters, Michael I. Vonk, Alexander B.A. van de Weerdt, Emma K. Kamminga, Suzanne Boer, Christa
Published in
Thrombosis Research
BackgroundHemostasis monitoring in cardiac surgery could benefit from an easy to use and fast point-of-care coagulation monitor, since routine laboratory tests have a delay of 30–45minutes. This study investigated the level of agreement between the point-of-care prothrombin time (PT) with central laboratory PT before and after cardiopulmonary bypas...
Irwin, Adriane N. Johnson, Samuel G. Joline, Brigitte R. Delate, Thomas Witt, Daniel M.
Published in
Thrombosis Research
IntroductionAlthough warfarin is often recommended for pulmonary arterial hypertension (PAH) management to mitigate thrombotic risk and improve survival, limited information exists to guide anticoagulation therapy. The purpose of this study was to compare and contrast warfarin therapy monitoring requirements and outcomes in patients with PAH and at...
Parand, Alireza Honar, Naser Aflaki, Khashayar Imanieh, Mohammad Hadi Haghighat, Mahmood Cohan, Nader Haghpanah, Sezaneh Marietta, Marco Serati, Zahra Haghbin, Saeedeh
...
Published in
Iranian Red Crescent medical journal
To evaluate the efficacy of prothrombin complex concentrate (PCC) in the management of bleeding in patients with liver disease and patients undergoing surgery or biopsy who had a high uncorrected international normalized ratio (INR). In this study, we examined an Iranian sample and investigated the efficacy of PCC to manage bleeding in patients wit...
Aggarwal, Harsh R Hassan, Ameer E Rodriguez, Gustavo J Suri, M Fareed K Taylor, Robert A Qureshi, Adnan I
Published in
Journal of vascular and interventional neurology
To determine the rates of symptomatic intracerebral hemorrhages (sICH), parenchymal hematoma type 2 (PH2), and favorable outcomes in patients with borderline elevation of international normalized ratio (INR) or recent anticoagulation use prior to treatment with intravenous recombinant tissue plasminogen activator (IV rt-PA) for acute ischemic strok...
Ibrahim, S Jespersen, J Poller, L
Published in
Journal of thrombosis and haemostasis : JTH
Patients with unstable anticoagulation have a significantly increased risk of 'clinical events' at 3 and 6 months before an event. The VGR can be incorporated into computer-dosage programs, and may offer additional safety when oral anticoagulation is monitored.
Witt, Daniel M Delate, Thomas Clark, Nathan P Garcia, David A Hylek, Elaine M Ageno, Walter Dentali, Francesco Crowther, Mark A
Published in
Thrombosis research
Repeatedly missing INR tests is an easily identified clinical parameter that is associated with moderately increased risk for thromboembolism in patients taking chronic warfarin therapy. Clinicians should carefully consider the underlying thromboembolic risk and extent of nonadherence when weighing the benefits of continued warfarin therapy for a g...
Theuwissen, E Teunissen, K J Spronk, H M H Hamulyák, K Ten Cate, H Shearer, M J Vermeer, C Schurgers, L J
Published in
Journal of thrombosis and haemostasis : JTH
Despite the worldwide use of vitamin K antagonists (VKAs), there is limited knowledge of the influence of dietary vitamin K on anticoagulation control. In view of the increasing nutraceutical availability of menaquinone-7 (MK-7; vitamin K2 ) and its promotion for bone and cardiovascular health, it is important to determine the posology for the inte...
Everson, Gregory T Hoefs, John C Niemann, Claus U Olthoff, Kim M Dupuis, Robert Lauriski, Shannon Herman, Andrea Milne, Norah Gillespie, Brenda W Goodrich, Nathan P
...
We quantified the rates of hepatic regeneration and functional recovery for 6 months after right hepatic lobectomy in living donors for liver transplantation. Twelve donors were studied pre-donation (baseline); 8 were retested at a mean ± SD of 11±3 days after donation (T1), 10 were retested at a mean of 91±9 days after donation (T2), and 10 were r...
