Capatina, Alina L Lagos, Dimitris Brackenbury, William J
Published in
Reviews of physiology, biochemistry and pharmacology
Ion channels are key regulators of cancer cell pathophysiology. They contribute to a variety of processes such as maintenance of cellular osmolarity and membrane potential, motility (via interactions with the cytoskeleton), invasion, signal transduction, transcriptional activity and cell cycle progression, leading to tumour progression and metastas...
Chatterjee, Avradip Paul, Sayan Bisht, Bharti Bhattacharya, Shelley Sivasubramaniam, Sudhakar Paul, Manash K
Published in
Drug discovery today
WNT/β-catenin signaling orchestrates various physiological processes, including embryonic development, growth, tissue homeostasis, and regeneration. Abnormal WNT/β-catenin signaling is associated with various cancers and its inhibition has shown effective antitumor responses. In this review, we discuss the pathway, potential targets for the develop...
Nguyen, Phuong Hoang Tufféry, Pierre Derreumaux, Philippe
Published in
Methods in molecular biology (Clifton, N.J.)
Amyloid fibril formation is an intrinsic property of short peptides, non-disease proteins, and proteins associated with neurodegenerative diseases. Aggregates of the Aβ and tau proteins, the α-synuclein protein, and the prion protein are observed in the brain of Alzheimer's, Parkinson's, and prion disease patients, respectively. Due to the transien...
Franco Pinto, Jaime
Glioma is the term coined for describing a vast group of primary cancers in the Central NervousSystem (CNS), whitin this group, we can find glioblastoma or glioblastoma multiforme (GBM) as the source of 60% of brain cancer in adults, having a peak in patients between 55 and 60 years. This type of brain cancer is a highly malignant and invasive tumo...
Ferrari, Erika
Metallic heritage artefacts represent cultural traces of our past, and for this reason, their preservation and transmission to future generations is important. To protect copper-based artworks exposed outdoors, several conservation strategies are followed, including the use of organic corrosion inhibitors. Inhibitors are usually borrowed from the i...
Gueniche, Nelly
Les pesticides forment une très vaste catégorie de contaminants environnementaux dont l’exposition est généralisée. De plus en plus d’études mettent en exergue des présomptions de liens entre des expositions aux pesticides et la survenue de pathologies. Parmi les acteurs clés du devenir et de la toxicité des xénobiotiques, figurent les transporteur...
Lopes, Helberth Júnnior Santos Bonturi, Nemailla Miranda, Everson Alves
Published in
Applied microbiology and biotechnology
The oleaginous yeast Rhodotorula toruloides is a potential lipid producer for biodiesel production. However, this yeast shows growth inhibition due to harmful compounds when cultivated in hemicellulose hydrolysate. Here, we present a comparative analysis of colony selection and heterologous adaptive laboratory enhancement (ALE) strategies for obtai...
Seaman, Craig D Xavier, Frederico Ragni, Margaret V
Published in
Hematology/oncology clinics of North America
Remarkable changes are occurring in the diagnosis and management of individuals with hemophilia A. Genetic testing, including next-generation sequencing, enables family planning, carrier testing, and prenatal diagnosis. Musculoskeletal ultrasound examination facilitates the early detection of acute bleeds and joint disease in clinic, enabling more ...
Ebob, Oyere Tanyi Babiaka, Smith B Ntie-Kang, Fidele
Published in
Natural products and bioprospecting
For the past 2 years, the coronavirus responsible for the COVID-19 infection has become a world pandemic, ruining the lives and economies of several nations in the world. This has scaled up research on the virus and the resulting infection with the goal of developing new vaccines and therapies. Natural products are known to be a rich source of lead...
Patel, Smith Bansoad, Ankush Vardhaman Singh, Rakesh Khatik, Gopal L
Published in
Current neuropharmacology
Alzheimer's disease (AD) is a chronic neurodegenerative disease where no specific disease-modifying treatment is currently available. β-secretase (BACE1) is considered the potential and rationale target because it is involved in the rate-limiting step, which produces toxic Aβ42 peptides leading to deposits in the form of amyloid plaques extracellul...
