Bajgai, Johny Xingyu, Jing Fadriquela, Ailyn Begum, Rahima Kim, Dong Heui Kim, Cheol-Su Kim, Soo-Ki Lee, Kyu-Jae
Published in
BMC Complementary Medicine and Therapies
BackgroundAtopic dermatitis (AD) is a chronic allergic inflammatory skin disease characterized by complex pathogenesis including skin barrier dysfunction, immune-redox disturbances, and pruritus. Prolonged topical treatment with medications such as corticosteroids, calcineurin inhibitors, and T-cell inhibitors may have some potential side-effects. ...
Cheon, So Yeong Lee, Jong Eun
Published in
Experimental Neurobiology
Immune system is essential for host homeostasis. Immune cells communicate with each other by binding to receptors or by releasing vesicles including chemokines and cytokines. Under healthy circumstances, immune cell-derived factors are critical for cellular growth, division and function, whereas under conditions such as ageing and inflammatory stat...
Cho, Eunsil Park, Jae-Yong
Published in
BMB reports
14-3-3 proteins are mostly expressed in the brain and are closely involved in numerous brain functions and various brain disorders. Among the isotypes of the 14-3-3 proteins, 14-3-3γ is mainly expressed in neurons and is highly produced during brain development, which could indicate that it has a significance in neural development. Furthermore, the...
Blondeel, J Mattuizzi, A Delmas, Y Skopinski, S Richez, C Blanco, P Sentilhes, L Lazaro, E
Published in
Gynecologie, obstetrique, fertilite & senologie
The pluridisciplinary meeting "PREGNANT - Pregnancy and Auto-immunity, Nephropathy, Thrombophilic Disorders" at the university hospital of Bordeaux is dedicated to inflammatory and thrombophilic disorders during pregnancy. The objective of our study was to evaluate the quality of this meeting in terms of: compliance with the mandatory criteria, ade...
Aeschlimann, Florence A; Dumaine, Cecile; Worner, Andreas; Mouy, Richard; Wouters, Carine; 34203; Melki, Isabelle; Uettwiller, Florence; Job-Deslandre, Chantal; Quartier, Pierre; Bader-Meunier, Brigitte;
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OBJECTIVES: To assess the incidence rate and type of serious adverse events (SAE) in children with rheumatic inflammatory diseases treated with the interleukin 6 blocker tocilizumab (TCZ). METHODS: A retrospective review of all consecutive patients diagnosed with an inflammatory rheumatic disease and receiving at least one dose of TCZ was performed...
Tang, Tao-Tao Wang, Bin Lv, Lin-Li Liu, Bi-Cheng
Published in
Theranostics
Dysregulated inflammation is a complicated pathological process involved in various diseases, and the treatment of inflammation-linked disorders currently represents an enormous global burden. Extracellular vesicles (EVs) are nanosized, lipid membrane-enclosed vesicles secreted by virtually all types of cells, which act as an important intercellula...
Guo, Lisa N Nambudiri, Vinod E
Published in
Clinical rheumatology
Multiple autoinflammatory diseases, including psoriasis, psoriatic arthritis, and systemic lupus erythematosus, have been linked to increased risk of cardiovascular disease. Inflammation is known to play a key role in the pathogenesis of atherosclerosis, thus the contribution of systemic immune dysregulation, which characterizes such inflammatory c...
Teng, Chao Lin, Chenshi Huang, Feifei Xing, Xuyang Chen, Shenyu Ye, Ling Azevedo, Helena S. Xu, Chenjie Wu, Zhengfeng Chen, Zhongjian
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Published in
Acta Pharmaceutica Sinica. B
Image 1 Targeted codelivery of anti-miR 155 and anti-inflammatory drug, baicalein, by using a carrier-free strategy effectively promotes polarization of macrophages from M1 toward M2 in vitro and in vivo . The codelivery system has prolonged blood-circulation time and can accumulate in the plaque after intravenous injection. The platform is potent ...
Wang, Shuyuan Zhou, Shunheng Liu, Haizhou Meng, Qianqian Ma, Xueyan Liu, Hui Wang, Lihong Jiang, Wei
Published in
BMC Genomics
BackgroundInflammation has been considered to be central to the onset, progression, and outcome of infectious diseases, especially as one of the hallmarks of cancer. Non-coding RNAs (ncRNAs), such as miRNAs and lncRNAs, have emerged as vital regulators in control of immune and inflammatory processes, and also play important roles in the inflammator...
Kim, Taehyeung Bae, Sang-Cheol Kang, Changwon
Published in
Arthritis Research & Therapy
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune inflammatory rheumatic disease. SLE susceptibility is affected by multiple genetic elements, environmental factors, and their interactions. We aimed in this study to statistically and functionally characterize a gene-gene interaction (epistasis) recently documented to affect SLE risk.Met...
