León-Janampa, Nancy Boennec, Natacha Le Tilly, Olivier Ereh, Simon Herbet, Gabriel Moreau, Alain Gatault, Philippe Longuet, Hélène Barbet, Christelle Büchler, Mathias
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Introduction: Hepatitis E virus (HEV) can cause chronic infection ($3 months) and cirrhosis in immunocompromised patients, especially kidney transplant recipients. Low alanine aminotransferase (ALT) levels and high HEV intrahost diversity have previously been associated with evolution toward chronicity in these patients. We hypothesized that additi...
Dykes, Kaitlyn Tzachanis, Dimitrios Koura, Divya
Post-allogeneic hematopoietic cell transplant (HCT) immunosuppression regimens are given as graft-versus-host disease (GVHD) prophylaxis. Most GVHD prophylaxis regimens are based on calcineurin inhibitors (CNIs). Unfortunately, CNIs are associated with significant associated morbidity, frequently cannot be tolerated, and often need to be discontinu...
Kim, Jon Jin Lawless, Laura Marshall, David Maxted, Andrew Lunn, Andrew Mallik, Meeta Williams, Alun
Publication status: Published / Funder: Chiesi Farmaceutici; doi: http://dx.doi.org/10.13039/100007560 / INTRODUCTION: Tacrolimus is the standard immunosuppressant for pediatric kidney transplants and is routinely administered twice daily (BD-tac). Envarsus (LCP-tac), an extended-release formulation, is approved for adults but not for pediatric pat...
Nguyen, Yann Blanchet, Benoît Urowitz, Murray Hanly, John Gordon, Caroline Bae, Sang-Cheol Romero-Diaz, Juanita Sanchez-Guerrero, Jorge Clarke, Ann Bernatsky, Sasha
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OBJECTIVE: The goals of this study were to assess the associations of severe nonadherence to hydroxychloroquine (HCQ), objectively assessed by HCQ serum levels, and risks of systemic lupus erythematosus (SLE) flares, damage, and mortality rates over five years of follow-up. METHODS: The Systemic Lupus International Collaborating Clinics (SLICC) Inc...
Zhang, David Adegunsoye, Ayodeji Oldham, Justin M Kozlitina, Julia Garcia, Nicole Poonawalla, Maria Strykowski, Rachel Linderholm, Angela L Ley, Brett Ma, Shwu-Fan
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BackgroundStudies suggest a harmful pharmacogenomic interaction exists between short leukocyte telomere length (LTL) and immunosuppressants in idiopathic pulmonary fibrosis (IPF). It remains unknown if a similar interaction exists in non-IPF interstitial lung disease (ILD).MethodsA retrospective, multicentre cohort analysis was performed in fibroti...
Lykhopiy, Valentina; Malviya, Vanshika; 131998; Humblet-Baron, Stephanie; 75170; Schlenner, Susan M.; 84381;
FOXP3+ regulatory T cells (Treg) are indispensable for immune homoeostasis and for the prevention of autoimmune diseases. Interleukin-2 (IL-2) signalling is critical in all aspects of Treg biology. Consequences of defective IL-2 signalling are insufficient numbers or dysfunction of Treg and hence autoimmune disorders in human and mouse. The restora...
Varady, Erika S Ayala, L Angel Nguyen, Pauline U Scarfone, Vanessa M Karimzadeh, Alborz Zhou, Cuiwen Chen, Xiyu Greilach, Scott A Walsh, Craig M Inlay, Matthew A
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Hematopoietic cell transplantation (HCT) treats many blood conditions but remains underused due to complications such as graft-versus-host disease (GvHD). In GvHD, donor immune cells attack the patient, requiring powerful immunosuppressive drugs like glucocorticoids (GCs) to prevent death. In this study, we tested the hypothesis that donor cell con...
Gowrishankar, Shravan Smith, Matthew E Creber, Nathan Muzaffar, Jameel Borsetto, Daniele
Acknowledgements: The authors are grateful to Veronica Phillips (Cambridge University Medical Librarian) for their help in creating and running the search for our systematic review. / Funder: Rinri Therapeutics Ltd / BACKGROUND: Pharmacologic immunosuppression regimes are commonly employed in stem cell clinical trials to mitigate host immune reject...
Geetha, Duvuru Dua, Anisha Yue, Huibin Springer, Jason Salvarani, Carlo Jayne, David Merkel, Peter group, advocate study
Peer reviewed: True / Acknowledgements: The authors thank all the many study coordinators, investigators and patients involved for their valuable contributions. Jon Nilsen, PhD and Rachel Gurlin, PhD (Amgen), provided medical writing support for this manuscript. / Funder: Amgen; FundRef: http://dx.doi.org/10.13039/100002429 / Funder: ChemoCentryx /...
David, Trixy Su, Li Cheng, Yafeng Gordon, Caroline Parker, Benjamin Isenberg, David Reynolds, John A Bruce, Ian N Hanly, John G Bae, Sang-Cheol
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BackgroundWe aimed to identify factors associated with a significant reduction in SLE disease activity over 12 months assessed by the BILAG Index.MethodsIn an international SLE cohort, we studied patients from their 'inception enrolment' visit. We also defined an 'active disease' cohort of patients who had active disease similar to that needed for ...
