Published in Bioscience reports
Interleukin-1 receptor type II (IL-1R2), also known as CD121b, is a member of the IL-1 receptor family. IL-1R2 acts as negative regulator of the IL-1 system, modulating IL-1 availability for the signaling receptor. IL-1R2 is abnormally expressed in many human inflammatory diseases and cancers, and has important clinical significance. The present st...
Published in Endocrine Pathology
Abdominal paragangliomas and pheochromocytomas (PPGLs) are rare neuroendocrine tumors of the infradiaphragmatic paraganglia and adrenal medulla, respectively. Although few pathologists outside of endocrine tertiary centers will ever diagnose such a lesion, the tumors are well known through the medical community—possible due to a combination of the ...
Published in Anais Brasileiros de Dermatologia
Background Cutaneous leiomyosarcoma is a rare malignant neoplasm with muscular origin, representing 2%-3% of all cutaneous soft tissue sarcomas. Objectives The aim of this study was to characterize clinicopathological features of patients diagnosed with cutaneous leiomyosarcoma in our center over the last 20-years. Methods A retrospective study of ...
Published in Scientific Reports
Oral squamous cell carcinoma (OSCC) is known for its aggressiveness associated with poor prognosis. The molecular mechanisms underlying the invasion and metastasis are still poorly understood. An improved understanding of these mechanisms shall precede the development of new diagnostic tools and targeted therapies. We report an integrated approach ...
Published in Urology Case Reports
• Testicular adult- type granulosa cell tumor (GCT) is extremely rare. • The immunohistochemistry for vimentin, inhibin and calretinin is consistently positive in testicular adult GCT. • The immunopositivity for estrogen receptor, progesterone receptor, androgen receptor, CD10 and CD56 is a characteristic of testicular adult GCT.
Published in Head and neck pathology
Upper aerodigestive tract (UADT) spindle cell squamous carcinoma (SCSC), also known as sarcomatoid carcinoma, is a high-grade subtype of conventional squamous cell carcinoma (SCC) that is histologically characterized by a combination of differentiated SCC in the form of intraepithelial dysplasia and/or invasive differentiated SCC, and the presence ...
Published in International Journal of Surgery Case Reports
Introduction and importance Although primary breast cancer is the most common tumor in women, breast metastases are rare findings. We report the first case in English literature with CRC metastases to the breast and adrenal gland concurrently. Case presentation A 42-year-old Caucasian female complained of abdominal pain over the last 3 days. Her hi...
Published in Diagnostic Pathology
BackgroundSialadenoma papilliferum (SP) is an extremely rare benign neoplasm of salivary glands. To explore and define the clinicopathological features of SP, we retrospectively analyzed 89 cases previously reported and five new cases.MethodsThe clinical features, histopathology, immunohistochemistry and molecular analysis of our cases were further...
Published in Medical Oncology
Assessing Erb-b2 receptor tyrosine kinase 2 (ERBB2) amplification status in breast and gastric cancer is necessary for deciding the best therapeutic strategy. Immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) are currently used for assessing protein levels and gene copy number (CN), respectively. The use of next-generation se...
Published in Machine Vision and Applications
To design a hybrid deep learning system (hDL-system) for discriminating low-grade from high-grade colorectal cancer (CRC) lesions, using immunohistochemically stained biopsy specimens for AIB1 expression. AIB1 has oncogenic function in tumour genesis, and it is an important prognostic factor regarding various types of cancers, including CRC. Clinic...
