Lee, Ji Yun Lee, Ju-Hyun Lee, Heeyoung Kang, Beodeul Kim, Ji-Won Kim, Se Hyun Lee, Jeong-Ok Kim, Jin Won Kim, Yu Jung Lee, Keun-Wook
...
Published in
Thrombosis research
The epidemiology of immune thrombocytopenia (ITP) is not well characterized in an Asian population. From July 2010 to June 2014, ITP patients were identified using the Korean Health Insurance Review and Assessment Service database. The overall incidence rate of ITP was 5.3 per 100,000 person-years (95% CI: 5.1-5.5). The overall incidence rate ratio...
Kindler, O. Karastaneva, A. Seidel, M. G.
Published in
Monatsschrift Kinderheilkunde
Autoimmunerscheinungen gehören zum Symptomspektrum primärer Immundefekte und -dysregulationserkrankungen (PID). Immunzytopenien treten am häufigsten bei B‑ oder T‑Zell-Defekten auf; Patienten mit PID haben ein gegenüber der Normalbevölkerung ca. 120-fach erhöhtes Risiko für eine Immunzytopenie. Bei Kindern und Jugendlichem mit chronischer Immunthro...
Saeidi, Sajedeh Mohammadi-Asl, Javad Far, Mohammad Ali Jalali Asnafi, Ali Amin Dehuri, Firouzeh Tavakolifar, Yousef Saki, Najmaldin
Published in
Indian Journal of Hematology and Blood Transfusion
Immune thrombocytopenia (ITP) is a common autoimmune disorder characterized by decreased platelet count (thrombocytopenia) and bleeding symptoms due to production of autoantibodies against platelets. Chemokines are molecules inducing chemotaxis and play an important role in megakaryopoiesis, including CXCR4 chemokine receptor. CXCR4 is expressed on...
Audia, Sylvain Mahévas, Matthieu Samson, Maxime Godeau, Bertrand Bonnotte, Bernard
Published in
Autoimmunity reviews
Immune thrombocytopenia (ITP) is a rare autoimmune disease due to an abnormal T cell response, notably supported by splenic T follicular helper cells, that stimulates the proliferation and differentiation of autoreactive B cells. The antiplatelet autoantibodies they produce facilitate platelet phagocytosis by macrophages, essentially in the spleen....
Carmo, Julia Cavalcante do Klippel, Prissyla de Souza Cordeiro, Sabrine da Costa Fernandes, Ângela Maria dos Santos Pinto, Raquel Medeiros Weber, Simone Schneider Fantin, Cleiton
ABSTRACT Background: Immune thrombocytopenia is an immune disease characterized by thrombocytopenia and bleeding due to platelet antibodies against platelet membrane glycoproteins. Human platelet antigens are derived from polymorphisms of these glycoproteins. The aim of this study was to investigate human platelet antigen frequencies in immune thro...
Melekoğlu, Nuriye Aslı Bay, Ali Aktekin, Elif H. Yilmaz, Mehmet Sivasli, Ercan
Published in
Indian Journal of Hematology and Blood Transfusion
Neonates born to mothers with immune thrombocytopenia (ITP) have an increased risk for neonatal thrombocytopenia and hemorrhagic complications. The aim of this study was to determine the maternal and neonatal outcomes of pregnancies with ITP and also to identify risk factors that predicts neonatal thrombocytopenia. We performed a retrospective anal...
Suntsova, Elena V. Demina, Irina M. Ignatova, Anastasia A. Ershov, Nikolay M. Trubina, Natalia M. Dobrynina, Juliya Serkova, Irina V. Supik, Zhanna S. Orekhova, Ekaterina V. Hachatryan, Lili A.
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Published in
International Journal of Hematology
It has been suggested that platelet function in chronic immune thrombocytopenic purpura (ITP) may be abnormal. Thrombopoietin mimetics used for treatment can affect it, but the data remain limited. We investigated platelet function of 20 children diagnosed with severe ITP (aged 1–16 years, 12 females and eight males). Platelet functional activity i...
Pincez, Thomas
Les atteintes neurologiques ont été peu décrites dans les cytopénies auto-immunes (CAI) et évoquent un déficit immunitaire primitif (DIP). Parmi les 1 167 enfants de la cohorte prospective française de CAI OBS’CEREVANCE, nous avons identifiés 8 patients avec une atteinte neurologique. Les données ont été récupérées auprès de chaque centre et les IR...
Badyal, Rama Kumari Sharma, Prashant Varma, Neelam Dhir, Varun Prakash, Gaurav
Published in
Indian Journal of Hematology and Blood Transfusion
Wang, Shuguo Liu, Fenghai Zhao, Hongguo
Published in
Indian Journal of Hematology and Blood Transfusion
To investigate the contribution and mechanism of eosinophil granulocytes and NK cells-mediated cytotoxicity to the pathogenesis of ITP. Mononuclear cells and platelets were prepared from the bone marrow of 16 ITP patients and 10 healthy controls. Separately, eosinophil granulocytes and NK cells were selected with magnetic microbeads. As the target ...
