Wang, Shuang Liu, Yang Li, Guosheng Feng, Qi Hou, Ming Peng, Jun
Published in
Thrombosis research
Primary immune thrombocytopenia (ITP) is a common acquired autoimmune hemorrhagic disease characterized by a low platelet count and increased risk of bleeding. However, some patients do not respond well to current therapeutic approaches. Further studies on pathogenesis and pathophysiology of ITP are needed to discover new therapeutic targets. We ex...
Muhsen, Ibrahim N Alahmari, Ali Alnahedh, Mohammed Alkhudair, Nora A Samarkandi, Hadeel El Fakih, Riad
Published in
Hematology/oncology and stem cell therapy
Huang, Ying-Chih Shih, Yu-Hung Lin, Ching-Yeh Chiu, Ping-Fang Kuo, Su-Feng Lin, Jen-Shiou Shen, Ming-Ching
Published in
International journal of hematology
A 66-year-old woman had experienced abnormal bleeding since the age of 7. Thrombocytopenia was not detected until she was 48, and immune thrombocytopenia was diagnosed at age 66. She also reported experiencing hearing disturbance since the age of 30 and acute renal failure since the age of 61 but reported no visual disturbance. Her younger son, who...
Cockrell, Dillon C. Kasthuri, Raj S. Altun, Ersan Rose, Tracy L. Milowsky, Matthew I.
Published in
Case Reports in Oncology
Immune thrombocytopenia (ITP) is a rare paraneoplastic syndrome of solid tumor malignancies. In previously described cases of renal cell carcinoma (RCC) associated with secondary ITP, treatment has consisted of nephrectomy, splenectomy, and corticosteroids. Here, we describe a case of metastatic RCC presenting with a right ventricular mass and subs...
Benlachgar, Naoufal Doghmi, Kamal Masrar, Azlarab Mahtat, El Mehdi Harmouche, Hicham Tazi Mezalek, Zoubida
Published in
Thrombosis research
Immature platelets or reticulated platelets are newly released thrombocytes. They can be identified by their large size and high RNA cytoplasm concentration. Immature platelet fraction (IPF) represents the percentage of immature circulative platelets to the total number of platelets. The development of analytical standardization of this hematologic...
Liu, Shu-Yan Yuan, Dai Sun, Rui-Jie Zhu, Jing-Jing Shan, Ning-Ning
Published in
Journal of thrombosis and thrombolysis
To investigate differences in the expression of plasma proteins in immune thrombocytopenia (ITP) and normal control groups, bone marrow samples were collected from 20 active ITP patients and 20 healthy controls. Quantitative proteomics analysis based on mass spectrometry was used to measure the protein levels and understand the protein networks. We...
Porcelijn, Leendert Schmidt, David E Oldert, Gonda Hofstede-van Egmond, Suzanne Kapur, Rick Zwaginga, Jaap Jan de Haas, Masja
Published in
Transfusion medicine reviews
To this day, immune thrombocytopenia (ITP) remains a clinical diagnosis made by exclusion of other causes for thrombocytopenia. Reliable detection of platelet autoantibodies would support the clinical diagnosis, but the lack of specificity and sensitivity of the available methods for platelet autoantibody testing limits their value in the diagnosti...
Koca Yozgat, Ayça Leblebisatan, Göksel Akbayram, Sinan Çınar Özel, Simge Karakaş, Zeynep Erduran, Erol Yılmaz, Şebnem Koçak, Ülker Ünal, Şule Özdemir, Gül Nihal
...
Published in
Turkish Journal of Hematology
Objective: Immune thrombocytopenia (ITP) is a rare autoimmune disease and hematologic disorder characterized by reduced platelet counts that can result in significant symptoms, such as bleeding, bruising, epistaxis, or petechiae. The thrombopoietin receptor agonist eltrombopag (EPAG) is a second-line agent used to treat chronic ITP purpura in adult...
Humbert, S Razanamahery, J Payet-Revest, C Bouiller, K Chirouze, C
Published in
Medecine et maladies infectieuses
Wang, Xiaoyue Xu, Yan Gui, Weiwei Hui, Feng Liao, Hui
Published in
Clinical and experimental medicine
To review the efficacy and safety of glucocorticoids combined with different regimens for treating severe immune thrombocytopenia (ITP). Eighty-five severe ITP patients from 2 tertiary hospitals treated with glucocorticoids were enrolled from January 2018 to May 2019 and divided into 4 treatment groups: group A (treated with glucocorticoids), group...
