Swathirajan, Chinnambedu Ravichandran Rameshkumar, Marimuthu Ragavan Solomon, Sunil Suhas Vignesh, Ramachandran Balakrishnan, Pachamuthu
Published in
Journal of global antimicrobial resistance
Pseudomonas aeruginosa is an important aetiological agent causing pneumonia, urinary tract infections and bacteraemia. High antibiotic use in nosocomial settings and for immunocompromised conditions results in increasing multidrug resistance. This study analysed the antimicrobial resistance profile of P. aeruginosa isolates in an HIV setting. A tot...
Bricheux, A Lenggenhager, L Hughes, S Karmime, A Lescuyer, P Huttner, A
Published in
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is increasingly employed to ensure adequate antibiotic exposure and slow emergence of resistance. Imipenem's therapeutic range has not been defined; we report plasma concentrations and clinical outcomes of patients receiving imipenem for bacterial infections. All hospitalized adult patien...
Bedenić, Branka Ladavac, Ranko Vranić-Ladavac, Mirna Barišić, Nada Karčić, Natalie Sreter, Katherina Bernadette Mihaljević, Slobodan Bielen, Luka Car, Haris Beader, Nataša
...
Published in
Acta Clinica Croatica
Phenotypic detection of metallo-β-lactamases (MBLs) in Acinetobacter (A.) baumannii is a serious challenge to clinical microbiologists. MBLs are inhibited by metal chelators such as ethylenediaminetetraacetic acid) (EDTA). Production of MBLs cannot be recognized based on resistance phenotype. Therefore, phenotypic tests using EDTA are recommended. ...
Li, Sanwang Xie, Feifan
Karlowsky, James A Lob, Sibylle H Young, Katherine Motyl, Mary R Sahm, Daniel F
Published in
Journal of global antimicrobial resistance
Relebactam inhibits Ambler class A and C β-lactamases. Imipenem/relebactam has completed one phase 3 clinical study of patients infected with imipenem-non-susceptible Gram-negative bacilli. Two more phase 3 clinical studies are in progress for the treatment of patients with hospital-acquired and ventilator-associated bacterial pneumonia, complicate...
Farooqui, Fizza Irfan, Seema Shakoor, Sadia Zafar, Afia
Published in
Journal of global antimicrobial resistance
Nocardiosis is an opportunistic infection that can present as cutaneous, pulmonary and/or disseminated disease depending on the host immunity. Treatment choices include trimethoprim/sulfamethoxazole (co-trimoxazole; SXT) and imipenem along with some other antibiotics. The Clinical and Laboratory Standards Institute (CLSI) recommends the broth micro...
Trifi, Ahlem Abdellatif, Sami Abdennebi, Cyrine Daly, Foued Nasri, Rochdi Touil, Yosr Ben Lakhal, Salah
Published in
Annals of Clinical Microbiology and Antimicrobials
BackgroundEmpiric antimicrobial therapy (EAMT) using imipenem/colistin is commonly prescribed as a first line therapy in critically ill patients with severe sepsis. We aimed to assess the appropriateness of prescribing imipenem/colistin as EAMT in ICU patients.MethodsA 3-year observational prospective study included ICU patients that required imipe...
Tran-Dinh, A Neulier, C Amara, M Nebot, N Troché, G Breton, N Zuber, B Cavelot, S Pangon, B Bedos, J P
...
Published in
The Journal of hospital infection
To assess the impact of the incidental relocation of an intensive care unit (ICU) on the risk of colonizations/infections with Pseudomonas aeruginosa exhibiting OprD-mediated resistance to imipenem (PA-OprD). The primary aim was to compare the proportion of PA-OprD among P. aeruginosa samples before and after an incidental relocation of the ICU. Th...
Sun, Zhizeng Hu, Liya Sankaran, Banumathi Prasad, BV Venkataram Palzkill, Timothy
New Delhi metallo-β-lactamase-1 exhibits a broad substrate profile for hydrolysis of the penicillin, cephalosporin and 'last resort' carbapenems, and thus confers bacterial resistance to nearly all β-lactam antibiotics. Here we address whether the high catalytic efficiency for hydrolysis of these diverse substrates is reflected by similar sequence ...
Zhang, Hui Kong, Haishen Yu, Yunsong Wu, Anhua Duan, Qiong Jiang, Xiaofeng Zhang, Shufang Sun, Ziyong Ni, Yuxing Wang, Weiping
...
Published in
BMC Infectious Diseases
BackgroundTo evaluate the susceptibility rates of aerobic and facultative Gram-negative bacterial isolates from Chinese intra-abdominal infections (IAI) and urinary tract infections (UTI) focusing on carbapenems and comparing their effectiveness between 2014 and 2015.MethodsA total of 2318 strains in 2015 (1483 from IAI and 835 from UTI) and 2374 s...
