NATURAL COMPOUNDS IN DRUG DISCOVERY. BIOLOGICAL ACTIVITY AND NEW TRENDS IN THE CHEMISTRY OF ISOQUINOLINE ALKALOIDS
Published in Medicinal Chemistry Research
No abstract available.
Published in Medicinal Chemistry Research
No abstract available.
Published in Organic & biomolecular chemistry
1,2-Disubstituted 1,2,3,4-tetrahydrobenz[g]isoquinoline-5,10-diones are prepared for the first time through an activated Pictet-Spengler reaction of the corresponding imines of 2-(1,4-dimethoxynaphth-2-yl)ethylamine in the presence of an acyl chloride and AlCl(3) followed by an oxidation with silver(II) oxide in nitric acid. Depending on the reacti...