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Akuta, Norio Suzuki, Fumitaka Hirakawa, Miharu Kawamura, Yusuke Sezaki, Hitomi Suzuki, Yoshiyuki Hosaka, Tetsuya Kobayashi, Masahiro Kobayashi, Mariko Saitoh, Satoshi
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Published in
Intervirology
Objective: To evaluate predictive factors of treatment efficacy to interferon (IFN)/ribavirin in patients infected with HCV genotype 1b (HCV-1b). Methods: This study investigated pretreatment predictors, including viral- (aa substitutions in core aa 70/91 and NS5A-ISDR/IRRDR) and host-related factors (genetic variation near IL28B gene), to 48-week ...
Kim, Soo Ryang El-Shamy, Ahmed Imoto, Susumu Kim, Ke Ih Ide, Yoshi-hiro Deng, Lin Shoji, Ikuo Tanaka, Yasuhito Hasegawa, Yutaka Ota, Mitsuhiro
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Published in
Journal of Gastroenterology
BackgroundThis study explores pretreatment predictive factors for ultimate virological responses to pegylated interferon-α (1.5 μg/kg/week) and ribavirin (600–1000 mg/day) (PEG-IFN/RBV) combination therapy for patients infected with hepatitis C virus (HCV)-1b and a high viral load.MethodsA total of 75 patients underwent PEG-IFN/RBV combination ther...
