Liu, Yang Chang, Juan Wang, Ping Yin, Qing-qiang Huang, Wei-wei Liu, Chao-qi Bai, Xian-xiao Zhu, Qun Gao, Tian-zeng Zhou, Pu
...
Published in
AMB Express
Deoxynivalenol (DON) is one of the mycotoxins most frequently encountering in cereal-based foods throughout the world. Saccharomyces cerevisiae was used to alleviate porcine jejunal epithelia cell (IPEC-J2) injury induced by DON in this study. The results indicated that cell viability and proliferation rates were significantly decreased when DON co...
Zhao, Yuan Zhang, Shiyao Zhang, Xiaodong Pan, Li Bao, Nan Qin, Guixin
Published in
International Journal of Food Engineering
Dissecting the inhibited variation of allergen absorption could contribute to the development of novel therapeutic or preventive treatments for food/feed allergies. This study investigated the effects of fructooligosaccharide (FOS) on the absorption, intracellular accumulation of intact or hydrolysed β-conglycinin in porcine intestinal epithelial c...
Jiang, Qian Liu, Gang Chen, Jiashun Yao, Kang Yin, Yulong
Published in
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Lipopolysaccharides (LPSs) act as virulence factors that trigger intestinal inflammation and thereby compromise the production of pigs worldwide. Intestinal diseases and dysfunction have been attributed to endoplasmic reticulum stress (ERS) and the subsequent apoptosis of intestinal epithelial cells. Therefore It is important to explore whether LPS...
Xiao, Zhiping Liu, Lujie Tao, Wenjing Pei, Xun Wang, Geng Wang, Minqi
Published in
Cellular Physiology and Biochemistry
Background/Aims: The intestinal mucosa forms a physical and metabolic barrier against the diffusion of pathogens, toxins, and allergens from the lumen into the circulatory system. Early weaning, a critical phase in swine production, can compromise intestinal barrier function through mucosal damage and alteration of tight junction integrity Maintena...
Fraeyman, Sophie Meyer, Evelyne Devreese, Mathias Antonissen, Gunther Demeyere, Kristel Haesebrouck, Freddy Croubels, Siska
The emerging Fusarium mycotoxins beauvericin (BEA) and enniatin (ENN) A, ENN A1, ENN B and ENN B1 gain increasing interest due to their highly prevalent contamination of cereals and cereal products. After oral intake, the gastro-intestinal tract is the first possible site of interaction. In the present in vitro study, the relative cytotoxicity of t...
Qi, K K Sun, Y Q Wan, J Deng, B Men, X M Wu, J Xu, Z W
Published in
Journal of animal physiology and animal nutrition
Because of rare glucagon-like peptide-2 (GLP-2) receptor (+) cells within the gut mucosa, the molecular mechanisms transducing the diverse actions of GLP-2 remain largely obscure. This research identified the naturally occurring intestinal cell lines that endogenously express GLP-2R and determined the molecular mechanisms of the protective effects ...
Tao, Xin Liu, Shujie Men, Xiaoming Xu, Ziwei
Published in
Biology Direct
BackgroundWeaning stress affects the small intestine of piglets. MiR-146b is differentially expressed in suckling and weaned piglets. In this study, we evaluated the effects of miR-146b on cell viability, proliferation, and apoptosis in IPEC-J2 cells.ResultsTransfection with miR-146b mimics successfully increased miR-146b levels by 1000× (P
Zhou, Xin Li, Yansen Li, ChunMei
Published in
Toxicology in vitro : an international journal published in association with BIBRA
A high‑zinc (Zn) diet has been found to promote growth performance in pigs, but causes cell apoptosis in the intestinal epithelium. To investigate the mechanism underlying the high dietary Zn-induced apoptosis in porcine small intestinal epithelium, IPEC-J2 cells (intestinal porcine epithelial cells) were used to determine the effect of Zn on cell ...
Ko, Seongyeol Gu, Min Jeong Kim, Cheol Gyun Kye, Yoon Chul Lim, Younggap Lee, Ji Eun Park, Byung-Chul Chu, Hyuk Han, Seung Hyun Yun, Cheol-Heui
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Published in
Antiviral research
Porcine epidemic diarrhea virus (PEDV) invades porcine intestinal epithelial cells (IECs) and causes diarrhea and dehydration in pigs. In the present study, we showed a suppression of PEDV infection in porcine jejunum intestinal epithelial cells (IPEC-J2) by an increase in autophagy. Autophagy was activated by rapamycin at a dose that does not affe...
Zhao, Yuan Liu, Dandan Zhang, Shiyao Pan, Li Qin, Guixin
Published in
International Journal of Food Engineering
Three major enzyme-hydrolyzed peptides have been produced after simulative digestion in vitro of soybean β-conglycinin. The intestinal barrier of IPEC-J2 induced by β-conglycinin enzyme-hydrolyzed peptides was evaluated in this study. The increased alkaline phosphatase (AP) activity was actually linearly correlated with the incubation time by the h...
