The future of cystic fibrosis care: a global perspective
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ABC transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942.
The CDK7 inhibitors (CDK7i) ICEC0942 and THZ1, are promising new cancer therapeutics. Resistance to targeted drugs frequently compromises cancer treatment. We sought to identify mechanisms by which cancer cells may become resistant to CDK7i. Resistant lines were established through continuous drug selection. ABC-transporter copy number, expression ...
Synthesis of sulfonimidamides from sulfenamides via an alkoxy-amino-λ6-sulfanenitrile intermediate
Sulfonimidamides are intriguing new motifs for medicinal and agrochemistry, and provide attractive bioisosteres for sulfonamides. However, there remain few operationally simple methods for their preparation. Here, for the first time the synthesis of NH-sulfonimidamides is achieved directly from sulfenamides, themselves readily formed in 1 step from...
Inhaled corticosteroid suppression of cathelicidin drives dysbiosis and bacterial infection in chronic obstructive pulmo...
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Bacterial infection commonly complicates inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD). The mechanisms of increased infection susceptibility and how use of the commonly prescribed therapy inhaled corticosteroids (ICS) accentuates pneumonia risk in COPD are poorly understood. Here, using analysis of samples from p...
Variation of Physical Parameters and Anomalous Healing Observation in Plasma Wound Healing
The plasma healing of acute wound on 56 hairless mice is examined and initiated by several externally controlled physical parameters such as driving frequency and power, duration and interval of plasma treatment, a fraction of air mixture, the gap distance between plasma and wound, and others. The variation of these physical parameters results in a...
Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates
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Short peptide cages have great potential applications in drug encapsulation and release because of excellent biocompatibility, biodegradability and multi-functionality originated from their abundant sequences. However, constructing short peptide cages are still a challenge, which is caused by the rapid kinetic and unlimited self-assembly behavior o...
Tripartite cell networks for glucose homeostasis
Controlling the excess and shortage of energy is a fundamental task for living organisms. Diabetes is a representative metabolic disease caused by the malfunction of energy homeostasis. The islets of Langerhans in the pancreas release long-range messengers, hormones, into the blood to regulate the homeostasis of the primary energy fuel, glucose. Th...
Identifying physical causes of apparent enhanced cyclization of short DNA molecules with a coarse-grained model
DNA cyclization is a powerful technique to gain insight into the nature of DNA bending. While the worm-like chain model provides a good description of small to moderate bending fluctuations, it is expected to break down for large bending. Recent cyclization experiments on strongly-bent shorter molecules indeed suggest enhanced flexibility over and ...
Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem...
Chitooligosaccharides (COS), the only cationic oligosaccharide in nature, have been demonstrated to have anti-tumor activity. However, the inhibitory effects of COS on different stages of tumor metastasis are still unknown, and it is not clear what stage(s) of tumor metastasis COS targeted. To study the inhibitory effects of a new partially acetyla...
Inhibition of Liver Tumor Cell Metastasis by Partially Acetylated Chitosan Oligosaccharide on A Tumor-Vessel Microsystem...
Chitooligosaccharides (COS), the only cationic oligosaccharide in nature, have been demonstrated to have anti-tumor activity. However, the inhibitory effects of COS on different stages of tumor metastasis are still unknown, and it is not clear what stage(s) of tumor metastasis COS targeted. To study the inhibitory effects of a new partially acetyla...
