Theodorou, Ioannis G Ruenraroengsak, Pakatip Gow, Andrew Schwander, Stephan Zhang, Junfeng Jim Chung, Kian Fan Tetley, Teresa D Ryan, Mary P Porter, Alexandra E
Published in
Nanotoxicology
Inhaled nanoparticles (NPs) have high-deposition rates in the alveolar region of the lung but the effects of pulmonary surfactant (PS) on nanoparticle bioreactivity are unclear. Here, the impact of PS on the stability and dissolution of ZnO nanowires (ZnONWs) was investigated, and linked with their bioreactivity in vitro with human alveolar epithel...
White, Rhiannon R Ponsford, Amy H Weekes, Michael P Rodrigues, Rachel B Ascher, David B Mol, Marco Selkirk, Murray E Gygi, Steven P Sanderson, Christopher M Artavanis-Tsakonas, Katerina
...
Published in
PLoS pathogens
Trichinella spiralis is a muscle-specific parasitic worm that is uniquely intracellular. T. spiralis reprograms terminally differentiated skeletal muscle cells causing them to de-differentiate and re-enter the cell cycle, a process that cannot occur naturally in mammalian skeletal muscle cells, but one that holds great therapeutic potential. Althou...
Luyckx, Thomas Verstraete, Matthias De Roo, Karel Van Der Straeten, Catherine Victor, Jan
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The three dimensional (3D) deformation of the superficial medial collateral ligament (sMCL) of the knee might play an important role in the understanding of the biomechanics of sMCL lesions. Therefore, the strain and deformation pattern of the sMCL during the range of motion were recorded in five cadaveric knees with digital image correlation. Duri...
Douglas, Timothy E L Krawczyk, Grzegorz Pamula, Elzbieta Declercq, Heidi A Schaubroeck, David Bucko, Miroslaw M Balcaen, Lieve Van Der Voort, Pascal Bliznuk, Vitaliy van den Vreken, Natasja M F
...
Published in
Journal of tissue engineering and regenerative medicine
Mineralization of hydrogels, desirable for bone regeneration applications, may be achieved enzymatically by incorporation of alkaline phosphatase (ALP). ALP-loaded gellan gum (GG) hydrogels were mineralized by incubation in mineralization media containing calcium and/or magnesium glycerophosphate (CaGP, MgGP). Mineralization media with CaGP:MgGP co...
Yue, Y Huo, F Zhang, Y. Chao, Jianbin Martínez-Máñez, Ramón Yin, C.
We report herein a highly selective and sensitive turn-on fluorescent probe (compound 1) with a fast response time (less than 2 min) for thiophenol detection based on an enhanced SNAr reaction between thiophenols and a sulfonyl-ester moiety covalently attach to curcumin. Reaction of 1 in Hepes-MeOH (1:1, v/v, pH 7.4) in the presence of 4-methylthio...
De Caluwé, T Vercruysse, C W J Declercq, H A Schaubroeck, D Verbeeck, R M H Martens, L C
Published in
Dental materials : official publication of the Academy of Dental Materials
Bioactive glasses (BAG) form, in contrast to formerly used implant materials, a stable bond with tissues, especially bone, when implanted. Nowadays BAGs are often mixed with a cement/composite that hardens in situ to broaden its applications in dentistry or orthopedics. The bioactivity and biocompatibility of possible BAG candidates for BAG-cement/...
dowall;, stuart
In light of the recent outbreak of Ebola virus (EBOV) disease in West Africa, there have been renewed efforts to search for effective antiviral countermeasures. A range of compounds currently available with broad antimicrobial activity have been tested for activity against EBOV. Using live EBOV, eighteen candidate compounds were screened for antivi...
xiaolei, cai bandla, aishwarya duo, mao guangxue, feng Qin, Wei lun-de, liao Thakor, Nitish Tang, Ben Zhong bin, liu
10.1002/adma.201601191 / ADVANCED MATERIALS / 28 / 39 / 8760-8765
Baeyens, Ann Naessens, Evelien Van Nuffel, Anouk Weening, Karin E Reilly, Anne-Marie Claeys, Eva Trypsteen, Wim Vandekerckhove, Linos Eyckerman, Sven Gevaert, Kris
...
Published in
Scientific reports
To facilitate studies on Vpr function in replicating HIV-1, we aimed to tag the protein in an infectious virus. First we showed that N-, but not C-terminal HA/FLAG tagging of Vpr protein preserves Vpr cytopathicity. Cloning the tags into proviral DNA however ablated viral production and replication. By construction of additional viral variants we c...
Bevan, CL Fletcher, CE Godfrey, JD Shibakawa, A Bushell, M
Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3ß as a important modulator of miR biogenesis at Microprocessor level. Repression of GSK3ß activity reduces Drosha activity towards pri-miRs, leading to accumulation of unprocessed pri-miRs and reduction of mature pri-miRs without altering...
