Biochemical activities of tubercidin 3', 5'-cyclic monophosphate in rat epididymal adipose tissue
Published in Biochemical Pharmacology
Failure of 6-thiogmp to inhibit guanylate kinase in intact cells
Published in Biochemical Pharmacology
Experiments have been performed that make necessary a modification of the hypothesis that 6-thioguanine produces cytotoxicity by a sequential blockade of the enzymes, ribosylamine-5-phos-phate: pyrophosphate phosphoribosyltransferase (PRPP-amidotransferase), inosinate dehydrogenase and guanylate kinase. L5178Y murine leukemia cells ( in vivo and in...
Inhibition of purine nucleobase transport in human erythrocytes and cell lines by papaverine
Published in Biochemical Pharmacology
Papaverine was found to be an effective inhibitor of hypoxanthine transport not only in human erythrocytes, but also in the human cell lines HL60 (myeloic) and U937 (monocytic). ic 50 values for inhibition of hypoxanthine influx ranged from 6 to 20 μM. In erythrocytes papaverine was found to be a non-competitive inhibitor of hypoxanthine equilibriu...
I-123 iofetamine single-photon computed emission tomography in rapid cycling bipolar disorder: A clinical study
Published in Biological Psychiatry
The regional distribution of I-123 iofetamine (IMP) in the brain of 12 patients with rapid cycling bipolar disorder was studied by single-photon computed emission tomography imaging. Patients who were either medication free (n = 4) or on lithium monotherapy (n = 8) were assessed serially in depressed/dysphoric, manic/hypomanic, or euthymic states. ...
The inflammation modulatory protein (IMP) of cowpox virus drastically diminishes the tissue damage by down-regulating ce...
Published in Molecular and Cellular Biochemistry
Vaccinia virus (VV) and other pathogenic poxviruses encode for a complement control protein. The VV complement control protein or VCP, was one of the first soluble microbial proteins postulated to have an active role in the immunomodulation of the host defense. Since then, 2 other poxviruses, including variola virus and cowpox virus (CPV), were fou...
Simultaneous determination of hypoxanthine, inosine and inosine 5′-monophosphate with serially connected three enzyme re...
Published in Analytica Chimica Acta
A biosensor system for simultaneous determination of hypoxanthine (H x ), inosine (H x R) and inosine 5′-monophosphate (IMP) was developed to measure fish freshness indices such as K i and H value in a convenient way. The biosensor which is composed of three enzyme reactors packed with enzyme-bonded chitosan porous beads (Chitopearl) was operated i...
Error analysis of measured cerebral vascular response to acetazolamide stress by I-123-IMP autoradiographic method with ...
Published in Annals of Nuclear Medicine
Objectives: Iodine-123 (123I)-labeledN-isopropyl-p-iodoamphetamine (IMP) has been used as a cerebral blood flow (CBF) tracer for single-photon emission computed tomography (SPECT), and measurements of the CBF response to acetazolamide stress by SPECT with IMP are widely used to assess cerebral vascular reserve. To quantitate CBF by means of SPECT w...
Overproduction of NAD+ and 5′-inosine monophosphate in the presence of 10 μM Mn2+ by a mutant of Corynebacterium ammonia...
Published in Archives of Microbiology
Corynebacterium ammoniagenes strain CH31 is thermosensitive due to a mutation in nucleotide reduction (nrdts). The strain was examined for nucleotide overproduction upon shifting the culture temperature to a range of elevated temperatures. No overproduction of NAD+ was detected in the control maintained at 27°C whereas NAD+ was accumulated extracel...
Indocyanine green-mediated photothrombosis with intravitreal triamcinolone acetonide for subfoveal choroidal neovascular...
Published in Graefe's Archive for Clinical and Experimental Ophthalmology
BackgroundThere is a need for alternative treatments for the management of exudative age-related macular degeneration (AMD). The purpose of this paper is to determine the feasibility, safety, and clinical effect of indocyanine green (ICG)-mediated photothrombosis (IMP) combined with intravitreal triamcinolone acetonide (TA) in patients with subfove...
Effects of tissue heterogeneity on cerebral vascular response to acetazolamide stress measured by an I-123-IMP autoradio...
...Published in Annals of Nuclear Medicine
ObjectivesSingle-photon emission computed tomography (SPECT) with iodine-123 (123I)-labeledN-isopropyl-p-iodoamphetamine (IMP) is widely used in measuring the cerebral blood flow (CBF) response to acetazolamide stress for assessment of cerebral vascular reserve. To quantitate CBF by means of SPECT with IMP, an autoradiographic (ARG) method has been...
