Effect of vitamin D supplementation on inflammation: protocol for a systematic review.
Published in BMJ open
CRD42016037104.
The gut microbiota plays a protective role in the host defence against pneumococcal pneumonia.
...Published in Gut
This study identifies the intestinal microbiota as a protective mediator during pneumococcal pneumonia. The gut microbiota enhances primary alveolar macrophage function. Novel therapeutic strategies could exploit the gut-lung axis in bacterial infections.
Exploring the Homeostatic and Sensory Roles of the Immune System
Immunology developed under the notion of the immune system exists to fight pathogens. Recently, the discovery of interactions with commensal microbiota that are essential to human health initiated a change in this old paradigm. Here, we argue that the immune system has major physiological roles extending far beyond defending the host. Immune and in...
Sialylated IgG-Fc: a novel biomarker of chronic inflammatory demyelinating polyneuropathy.
Published in Journal of neurology, neurosurgery, and psychiatry
Sialylation in Fc portion of IgG plays a crucial role in the pathogenesis of autoimmune diseases and the working mechanism of intravenous immunoglobulin (IVIG). We aim to test whether IgG-Fc sialylation is a biomarker of disease activity for chronic inflammatory demyelinating polyneuropathy (CIDP). By using specific lectins for sialylation, galacto...
Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status.
...Published in Gut
Evidence suggests protective effects of vitamin D and antitumour immunity on colorectal cancer risk. Immune cells in tumour microenvironment can convert 25-hydroxyvitamin D [25(OH)D] to bioactive 1α,25-dihydroxyvitamin D3, which influences neoplastic and immune cells as an autocrine and paracrine factor. Thus, we hypothesised that the inverse assoc...
Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus au...
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We investigated the evolution and epidemiology of a novel live-stock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes and infects urban-dwelling Danes even without a Danish animal reservoir. Genetic evidence suggests both poultry and human adaptation, with poultry meat implicated as a probable source.
Long-term tryptophan supplementation decreased the welfare and innate immune status of pikeperch juveniles
It has been demonstrated that short-term supplementation of L-tryptophan (TRP) can mitigate the primary neuroendocrine response to stress in some fish species, but such stress reduction was reported to be both dose- and context-dependent (Basic et al, 2013; Machado et al, 2015). So, the TRP responses may be species related or depend on the stress l...
The Non-structural Protein 5 and Matrix Protein Are Antigenic Targets of T Cell Immunity to Genotype 1 Porcine Reproduct...
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The porcine reproductive and respiratory syndrome virus (PRRSV) is the cause of one of the most economically important diseases affecting swine worldwide. Efforts to develop a next-generation vaccine have largely focused on envelope glycoproteins to target virus-neutralizing antibody responses. However, these approaches have failed to demonstrate t...
Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus au...
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We investigated the evolution and epidemiology of a novel live-stock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes and infects urban-dwelling Danes even without a Danish animal reservoir. Genetic evidence suggests both poultry and human adaptation, with poultry meat implicated as a probable source.
Streptococcus agalactiae Serotype IV in Humans and Cattle, Northern Europe
Streptococcus agalactiae is an emerging pathogen of nonpregnant human adults worldwide and a reemerging pathogen of dairy cattle in parts of Europe. To learn more about interspecies transmission of this bacterium, we compared contemporaneously collected isolates from humans and cattle in Finland and Sweden. Multilocus sequence typing identified 5 s...
