Schlüter, Birgitta Gerhards, Roswitha Strumberg, Dirk Voigtmann, Rudolf
Published in
Journal of Cancer Research and Clinical Oncology
PurposeHer2/neu protein overexpression and gene amplification is found in 20–30% of breast cancer patients and correlates with poor clinical outcome. Patients who profit from anti-Her2/neu- therapy are routinely selected by examination of tumour specimens using immunohistochemistry (IHC) and fluorescence in situ hybridisation (FISH) separately. Man...
Tunca, Berrin Pedroni, Monica Cecener, Gulsah Egeli, Unal Borsi, Enrica Zorluoglu, Abdullah Gregorio, Carmela Di Yilmazlar, Tuncay Yerci, Omer de Leon, Maurizio Ponz
...
Published in
Familial Cancer
Hereditary non-polyposis colorectal cancer (HNPCC or Lynch syndrome) is caused by the inheritance of a mutant allele of a DNA mismatch repair gene. We aimed to investigate types and frequencies of mismatch repair (MMR) gene mutations in Turkish patients with HNPCC and to identify specific biomarkers for early diagnosis of their non-symptomatic kind...
Cecener, Gulsah Tunca, Berrin Egeli, Unal Bekar, Ahmet Guler, Gulnur Tolunay, Sahsine Aksoy, Kaya
Published in
Cellular and Molecular Neurobiology
Molecular studies have an important role in the elucidation of the mechanisms involved in Glioblastoma multiforme (GBM) development. The occurrence of FHIT gene alterations, which has an important role in different cancers, has not yet been studied well in GBM. We aimed to investigate the occurrence of alterations of FHIT gene sequence and protein ...
Choudhury, Kingshuk Roy Yagle, Kevin J Swanson, Paul E Krohn, Kenneth A Rajendran, Joseph G
Published in
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
Identifying and scoring cancer markers plays a key role in oncology, helping to characterize the tumor and predict the clinical course of the disease. The current method for scoring immunohistochemistry (IHC) slides is labor intensive and has inherent issues of quantitation. Although multiple attempts have been made to automate IHC scoring in the p...
di cataldo, s. ficarra, e. acquaviva, a. macii, e.
This paper presents two automated methods for the segmentation ofimmunohistochemical tissue images that overcome the limitations of themanual approach aswell as of the existing computerized techniques. The first independent method, based on unsupervised color clustering, recognizes automatically the target cancerous areas in the specimen and disreg...
Ganguli-Indra, Gitali Liang, Xiaobo Hyter, Stephen Leid, Mark Hanifin, Jon Indra, Arup K
Published in
Experimental dermatology
Chicken ovalbumin upstream promoter-transcription factor-interacting protein 2 (CTIP2) is a transcriptional regulator that is highly expressed in skin during mouse development, as well as in proliferating cells of adult mouse skin. We investigated expression of CTIP2 along with proliferation marker Ki-67 in normal human skin, and in skin from atopi...
Yusenko, Maria V Zubakov, Dmitry Kovacs, Gyula
Published in
International journal of biological sciences
Due to overlapping morphology, malignant chromophobe renal cell carcinomas (RCC) and benign renal oncocytomas (RO) may pose a diagnostic problem. In the present study, we have applied different algorithms to evaluate the data sets obtained by hybridisation of pooled and also individual samples of renal cell tumours (RCT) onto two different gene exp...
Ashok, Mahima
HER2 breast cancer is an aggressive disease that occurs in 20 - 30% of the breast cancer population. Treatment for HER2 breast cancer includes use of an anti-HER2 monoclonal antibody, trastuzumab. Testing for HER2 is of critical importance due to the adverse side effects and substantial costs associated with this anti-HER2 treatment. Currently, two...
Cecener, Gulsah Tunca, Berrin Egeli, Unal Bekar, Ahmet Guler, Gulnur Vatan, Ozgur Tolunay, Sahsine
Published in
Cellular and Molecular Neurobiology
The MMAC/PTEN tumor suppressor gene has an essential biological role in the formation of glioblastomas. It is known that there are variations in genetic alterations in tumors that develop in patients with different ethnic backgrounds; thus, we aimed to evaluate the incidence of MMAC/PTEN mutations and protein expression among various low grade glio...
Petrini, S. Barocci, S. Gavaudan, S. Villa, R. Briscolini, S. Sabbatini, M. Mattozzi, C. Barchiesi, F. Salamida, S. Ferrari, M.
...
Published in
European Journal of Wildlife Research
The lesions observed in 16 wild boars, hunted in central Italy, led to the suspect that could be related to the infection by porcine circovirus type 2 (PCV2). The animals had macroscopic and histological lesions in the lungs, tonsils, and bronchial lymph nodes. PCV2 was detected in tissue samples by polymerase chain reaction (PCR) and immunohistoch...
