Technological dynamics of Early Iron Age ceramics from the Heuneburg (SW Germany): A synthesis of 50 years of research
status: published
Genomic Detection of the Emerging, Highly Pathogenic HIV-1 Subtype D in Bahia, Northeast Brazil
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(1) Background: The HIV subtype D is generally associated with a faster decline in CD4+ T cell counts, a higher viral load, and a faster progression to AIDS. However, it is still poorly characterized in Brazil. In this study, we used genomics and epidemiological data to investigate the transmission dynamics of HIV subtype D in the state of Bahia, N...
The Human PDZome 2.0: Characterization of a New Resource to Test for PDZ Interactions by Yeast Two-Hybrid
PSD95-disc large-zonula occludens (PDZ) domains are globular modules of 80-90 amino acids that co-evolved with multicellularity. They commonly bind to carboxy-terminal sequences of a plethora of membrane-associated proteins and influence their trafficking and signaling. We previously built a PDZ resource (PDZome) allowing us to unveil human PDZ int...
Towards the most pragnant Gestalt: Leveling and sharpening as contextually dependent adaptive strategies
Gestalt psychologists posited that we always organize our visual input in the best way possible under the given conditions. Both weakening or removing unnecessary details (i.e., leveling) and exaggerating distinctive features (i.e., sharpening) can contribute to achieving a better organization. When is a feature leveled or sharpened, however? We in...
Myokines as mediators of exercise-induced cognitive changes in older adults: protocol for a comprehensive living systema...
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BACKGROUND: The world's population is aging, but life expectancy has risen more than healthy life expectancy (HALE). With respect to brain and cognition, the prevalence of neurodegenerative disorders increases with age, affecting health and quality of life, and imposing significant healthcare costs. Although the effects of physical exercise on cogn...
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
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The cell-autonomous balance of immune-inhibitory and -stimulatory signals is a critical process in cancer immune evasion. Using patient-derived co-cultures, humanized mouse models, and single-cell RNA-sequencing of patient melanomas biopsied before and on immune checkpoint blockade, we find that intact cancer cell-intrinsic expression of CD58 and l...
Mapping Peptide-Protein Interactions by Amine-Reactive Cleavable Photoaffinity Reagents
Photoaffinity labeling followed by tandem mass spectrometry is an often used strategy to identify protein targets of small-molecule drugs or drug candidates, which, under ideal conditions, enables the identification of the actual drug binding site. In the case of bioactive peptides, however, identifying the distinct binding site is hampered because...
Can common dietary assessment methods be better designed to capture the nutritional contribution of neglected, forest, a...
Published in Frontiers in Nutrition
Food systems are the primary cause of biodiversity loss globally. Biodiversity and specifically, the role that wild, forest and neglected and underutilised species (NUS) foods might play in diet quality is gaining increased attention. The narrow focus on producing affordable staples for dietary energy has contributed to largely homogenous and unhea...
Development of a tractable model system to study microbial community succession during wood-ageing of beer on a lab scal...
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Wood-ageing of conventionally fermented beers is gaining increased attention in the production of sour beers with a noteworthy balance between sourness, wood aroma and flavour complexity due to the extraction of wood-derived compounds and the activity of many ‘wild’ microorganisms. However, up until now wood-ageing of craft beers remains an unpredi...
Towards automatic insect monitoring on witloof chicory fields using sticky plate image analysis
status: accepted
