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Sun, Hao Du, Yanan Yao, Ming Wang, Qin Ji, Kaihua Du, Liqing Xu, Chang He, Ningning Wang, Jinhan Zhang, Manman
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Published in
Journal of cellular and molecular medicine
Tumour radioresistance is a major problem for cancer radiation therapy. To identify the underlying mechanisms of this resistance, we used human non-small cell lung cancer (NSCLC) cell lines and focused on the Inhibitor of Apoptosis Protein (IAP) family, which contributes to tumourigenesis and chemoresistance. We investigated the possible correlatio...
Athanasoula, Kalliopi Ch. Gogas, Helen Polonifi, Katerina Vaiopoulos, Aristeidis G. Polyzos, Aristidis Mantzourani, Marina
Published in
Cancer Letters
Survivin, a member of the inhibitor of apoptosis protein family, has been associated with protection from cell apoptosis and regulation of mitosis. Survivin exhibits low to undetectable expression in most finally differentiated adult tissues but is abundantly over-expressed in almost all cancers. The aberrant high expression of survivin in cancers ...
Wang, Kewei Lin, Bingliang Brems, John J. Gamelli, Richard L.
Published in
Apoptosis
Apoptotic injury participates in hepatic fibrosis, but the molecular mechanisms are not well understood. The present study aimed to investigate the role of inducible TIMP1 in the pathogenesis of hepatic apoptosis-fibrosis. Apoptosis was induced with GCDC, LPS, and alcohol in precision-cut liver slices or bile duct ligation (BDL) in rats, as reflect...
