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BackgroundLaunaea procumbens Asteraceae is used as a folk medicine to treat hepatic disorders in Pakistan The effect of a chloroform extract of Launaea procumbens LPCE was evaluated against carbon-tetrachloride CCl4 -induced liver damage in rats MethodsTo evaluate the hepatoprotective effects of LPCE 36 male Sprague Dawley rats were equally divided into six groups Animals of group 1 control had free access to food and water Group II received 3 ml kg of CCl4 30 in olive oil v v via the intraperitoneal route twice a week for 4 weeks Group III received 1 ml of silymarin via gavage 100 mg kg b w after 48 h of CCl4 treatment whereas groups IV and V were given 1 ml of LPCE 100 and 200 mg kg b w respectively after 48 h of CCl4 treatment Group VI received 1 ml of LPCE 200 mg kg b w twice a week for 4 weeks The activities of the antioxidant enzymes catalase peroxidase POD superoxide dismutase SOD glutathione peroxidase GSH-Px glutathione S-transferase GST glutathione reductase GSR glutathione GSH and lipid peroxidation thiobarbituric acid reactive substances TBARS were measured in liver homogenates DNA damage argyrophilic nucleolar organizer regions AgNORs counts and histopathology were studied in liver samples Serum was analyzed for various biochemical parameters Phytochemical composition in LPCE was determined through high-performance liquid chromatography HPLC ResultsLPCE inhibited lipid peroxidation and reduced the activities of aspartate transaminase alanine transaminase alkaline phosphatase and lactate dehydrogenase in serum induced by CCl4 GSH contents were increased as were the activities of antioxidant enzymes catalase SOD GST GSR GSH-Px when altered due to CCl4 hepatotoxicity Similarly absolute liver weight relative liver weight and the number of hepatic lesions were reduced with co-administration of LPCE Phyochemical analyses of LPCE indicated that it contained catechin kaempferol rutin hyperoside and myricetin ConclusionThese results indicated that Launaea procumbens efficiently protected against the hepatotoxicity induced by CCl4 in rats possibly through the antioxidant effects of flavonoids present in LPCE

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Hepatoprotection with a chloroform extract of Launaea procumbens against CCl4-induced injuries in rats

Publication search
with Hepatic Injuries as keyword