Besnier, Marie Gasparino, Stefano Vono, Rosa Sangalli, Elena Facoetti, Amanda Bollati, Valentina Cantone, Laura Zaccagnini, Germana Maimone, Biagina Fuschi, Paola
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Published in
Molecular therapy : the journal of the American Society of Gene Therapy
Therapies based on circulating proangiogenic cells (PACs) have shown promise in ischemic disease models but require further optimization to reach the bedside. Ischemia-associated hypoxia robustly increases microRNA-210 (miR-210) expression in several cell types, including endothelial cells (ECs). In ECs, miR-210 represses EphrinA3 (EFNA3), inducing...
Prior, Lucy; Manley, David; Jones, Kelvyn; 71464;
Deprived neighbourhoods have long been associated with poorer health outcomes. However, many quantitative studies have not evidenced the mechanisms through which place 'gets under the skin' to influence health. The increasing prevalence of biosocial data provides new opportunities to explore these mechanisms and incorporate them into models of cont...
McKay, AJ Hogan, H Humphries, S Marks, D Ray, K Miners, A
Background and aims: Familial hypercholesterolaemia (FH) is widely underdiagnosed. Cascade testing (CT) of relatives has been shown to be feasible, acceptable and cost-effective in the UK, but requires a supply of index cases. Feasibility of universal screening (US) at age 1–2 years was recently demonstrated. We examined whether this would be a cos...
Hatleberg, Camilla I Ryom, Lene El-Sadr, Wafaa Mocroft, Amanda Reiss, Peter De Wit, Stephane Dabis, Francois Pradier, Christian Monforte, Antonella d'Arminio Kovari, Helen
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Introduction: There is paucity of data related to potential gender differences in the use of interventions to prevent and treat cardiovascular disease (CVD) among HIV-positive individuals. We investigated whether such differences exist in the observational D:A:D cohort study. Methods: Participants were followed from study enrolment until the earlie...
Shah, Benoy N MacNab, Anita Lynch, Jane Hampson, Reinette Senior, Roxy Steeds, Richard P
Published in
Echo research and practice
Stress echocardiography is a widely utilised test in patients with known or suspected coronary artery disease (CAD), valvular heart disease and cardiomyopathies. Its advantages include the ubiquitous availability of echocardiography, lack of ionising radiation, choice of physiological or pharmacological stressors, good diagnostic accuracy and robus...
De Meyer, Tim Nawrot, Tim Bekaert, Sofie De Buyzere, Marc Rietzschel, Ernst Andrés, Vicente
Ven, Sofie Decloedt, Annelies De Clercq, Dominique Vera, Lisse Rademakers, F van Loon, Gunther
Background: Aortic regurgitation (AR) can have an important clinical impact and in some cases leads to left ventricular (LV) failure. Tissue Doppler imaging (TDI) is an echocardiographic technique that has been used in horses to detect LV dysfunction. Objectives: To examine whether TDI detects changes in radial myocardial wall motion in horses with...
van Aart, Carola Nawrot, Tim S Sioen, Isabelle De Boever, Patrick Zaqout, Mahmoud De Henauw, Stefaan Michels, Nathalie
Background: Retinal microvessels provides a window to assess the microcirculation of heart and brain, and might reflect cardio- or cerebrovascular disease risk. Limited information exist on the relation between psychosocial stress and the microcirculation, even though psychosocial stress might trigger vascular diseases. This study investigates whet...
Baruteau, Alban-Elouen Abrams, Dominic J Ho, Siew Yen Thambo, Jean-Benoit McLeod, Christopher J Shah, Maully J
Published in
Journal of the American Heart Association
Matinolli, Hanna-Maria Männistö, Satu Sipola-Leppänen, Marika Tikanmäki, Marjaana Heinonen, Kati Eriksson, Johan G Wolke, Dieter Lano, Aulikki Järvelin, Marjo-Riitta Vääräsmäki, Marja
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Published in
Pediatric Research
BackgroundAdults born preterm have higher levels of cardiometabolic risk factors than their term-born peers. Studies have suggested that at least those born smallest eat less healthily. We examined the association between early (
