My Medication Passport has been positively evaluated; we have a better understanding of how it is used by patients, what they are recording and how it can be an aid to dialogue about medicines with family, carers and healthcare professionals. Further development and spread is underway including an App for smartphones that will be subject to wider e...
BackgroundThis review is an update of the first Cochrane publication on selenium for preventing cancer (Dennert 2011).Selenium is a metalloid with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancers.ObjectivesTwo research questions were addr...
Duru, O KenrikEttner, Susan LTurk, NormanMangione, Carol MBrown, Arleen FFu, JefferySimien, LeslieTseng, Chien-Wen
BackgroundDrug substitution is a promising approach to reducing medication costs.ObjectiveTo calculate the potential savings in a Medicare Part D plan from generic or therapeutic substitution for commonly prescribed drugs.DesignCross-sectional, simulation analysis.ParticipantsLow-income subsidy (LIS) beneficiaries (n = 145,056) and non low-income s...
Day, Timothy PByrne, Leah CSchaffer, David VFlannery, John G
Adeno-associated virus (AAV) is a small, non-pathogenic dependovirus that has shown great potential for safe and long-term expression of a genetic payload in the retina. AAV has been used to treat a growing number of animal models of inherited retinal degeneration, though drawbacks-including a limited carrying capacity, slow onset of expression, an...
Despite the development of numerous novel antiepileptic drugs (AEDs) in recent years, several unmet clinical needs remain, including resistance to AEDs in about 30 % of patients with epilepsy, adverse effects of AEDs that can reduce quality of life, and the lack of treatments that can prevent development of epilepsy in patients at risk. Animal mode...
't Mannetje, AndreaCoakley, JonathanBridgen, PhilSmith, Allan HRead, DeborahPearce, NeilDouwes, Jeroen
AimTo estimate average infant daily intake of chlorinated persistent organic pollutants (POPs) through the consumption of breast milk in New Zealand.MethodBreast milk of 39 first-time mothers aged 20-30 years was collected during 2007-2010 and analysed for persistent organic pollutants including dioxin-like compounds and organochlorine pesticides. ...
