Diagnosis and treatment of COVID-19 associated pulmonary apergillosis in critically ill patients: results from a Europea...
status: published
Supported online self-management versus care as usual for symptoms of fatigue, pain and urgency/incontinence in adults w...
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Background Despite being in clinical remission, many people with inflammatory bowel disease (IBD) live with fatigue, chronic abdominal pain and bowel urgency or incontinence that limit their quality of life. We aim to test the effectiveness of an online self-management programme (BOOST), developed using cognitive behavioural principles and a theore...
Risk of incident fractures in individuals hospitalised due to unexplained syncope and orthostatic hypotension
Background Impaired orthostatic blood pressure response and syncope confer a high risk of falls and trauma. The relationship between a history of unexplained syncope and orthostatic hypotension (OH) with subsequent fractures, however, has not been thoroughly examined. In this study, we aimed to investigate the relationship between previous hospital...
CERN-MEDICIS: A Review Since Commissioning in 2017
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The CERN-MEDICIS (MEDical Isotopes Collected from ISolde) facility has delivered its first radioactive ion beam at CERN (Switzerland) in December 2017 to support the research and development in nuclear medicine using non-conventional radionuclides. Since then, fourteen institutes, including CERN, have joined the collaboration to drive the scientifi...
Public preferences for delayed or immediate antibiotic prescriptions in UK primary care: a choice experiment
Delayed (or ‘back-up’) antibiotic prescription, where the patient is given a prescription but advised to delay initiating antibiotics, has been shown to be effective in reducing antibiotic use in primary care. However, this strategy is not widely used in the UK. This study aimed to identify factors influencing preferences among the UK public for de...
A Review of Irritable Bowel Syndrome
status: published
Understanding the benefits and burdens associated with a malaria human infection study in Kenya: experiences of study vo...
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BACKGROUND: Human infection studies (HIS) that involve deliberately infecting healthy volunteers with a pathogen raise important ethical issues, including the need to ensure that benefits and burdens are understood and appropriately accounted for. Building on earlier work, we embedded social science research within an ongoing malaria human infectio...
Attitudes towards trusting artificial intelligence insights and factors to prevent the passive adherence of GPs: a pilot...
Artificial Intelligence (AI) systems could improve system efficiency by supporting clinicians in making appropriate referrals. However, they are imperfect by nature and misdiagnoses, if not correctly identified, can have consequences for patient care. In this paper, findings from an online survey are presented to understand the aptitude of GPs (n =...
Symptoms and signs of colorectal cancer, with differences between proximal and distal colon cancer: a prospective cohort...
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BACKGROUND: In an abdominal symptom study in primary care in six European countries, 511 cases of cancer were recorded prospectively among 61,802 patients 16 years and older in Norway, Denmark, Sweden, Netherlands, Belgium and Scotland. Colorectal cancer is one of the main types of cancer associated with abdominal symptoms; hence, an in-depth subgr...
Randomized Trial of Fetal Surgery for Moderate Left Diaphragmatic Hernia
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BACKGROUND: Fetoscopic endoluminal tracheal occlusion (FETO) has been associated with increased postnatal survival among infants with severe pulmonary hypoplasia due to isolated congenital diaphragmatic hernia on the left side, but data are lacking to inform its effects in infants with moderate disease. METHODS: In this open-label trial conducted a...
